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1、早期应用双磷酸盐在晚期前列腺癌治疗中作用DOI：10.16662/j.cnki.1674-0742.2017.11.115［摘要］目的探□早期静脉应用双磷酸盐对晚期前列腺癌进展及骨转移发生时间的影响。方法随机选择2014年12月一2016年12月期间该院收治的40例晚期前列腺癌患者作为研究对象，并随机分为观察组和对照组，两组患者均给予常规治疗，对照组未早期应用双磷酸盐，观察组给予早期应用双磷酸盐，观察两组患者的无进展生存期、骨转移发生率、骨转移发生时间、总生存期等、不良反应发生情况。结果观察组的平均无进展生存期为(20.3±0.6)个月，对照组的平均无进展生存期为(15.3
2、±1.6)个月，组间比较差异有统计学意义(t=0.365,P=0.025)；观察组患者的骨转移率(20.0%)显著高于对照组(60.0%),差异有统计学意义(x2=1.014,P=0.000),且骨转移时间较对照组延迟近4个月，两组的骨转移时间和骨转移发生率比较差异有统计学意义(t=0.897,P=0.004；t=3.365,P=0.0⑷。结论早期应用双磷酸盐治疗晚期前列腺癌能够显著缓解疾病进程，降低骨转移患者发生骨相关事件的发生几率，延长患者的生命周期和生存质量。［关键词］前列腺癌；早期应用；双磷酸盐；骨密度［中图分类号］R737.25［文献标识码］A［文章编号］1674
3、-0742(2017)04(b)-0115-03EffectofEarlyApplicationofBisphosphonatesintheTreatmentofAdvancedProstaticCarcinomaYUZhi-yongDepartmentofUrinarySurgery,XishuangbarmaPeople，sHospital,Jinghong,YunnanProvince,666100China［Abstract］ObjectiveTostudytheeffectofearlyintravenousapplicationofbisphosphonates
4、ontheprogressofadvancedprostaticcarcinomaandoccurrencetimeofosseousmetastasis・Methods40casesofpatientswithadvancedprostaticcarcinomaadmittedandtreatedinourhospitalfromDecember2014toDecember2016wererandomlyselectedandrandomlydividedintotwogroups,bothgroupsweregiventheroutinetreatment,thecon
5、trolgroupdidnotapplythebisphosphonatesintheearlystage,whiletheobservationgroupadoptedtheearlyapplicationofbisphosphonates,andtheprogression-freesurvival,incidencerateofosseousmetastasis,occurrencetimeofosseousmetastasis,totalsurvivalandoccurrenceofadversereactionsofthetwogroupswereobserved
6、・ResuItsThedifferenceintheaverageprogression-freesurvivalbetweentheobservationgroupandthecontrolgroupwasstatisticallysignificant[(20.3±0.6)monthsvs(15.3±1.6)months](t=0.365,P=0.025),andtheosseousmetastasisrateintheobservationgroupwasobviouslyhigherthanthatinthecontrolgroup(20.0%vs60.0%),an
7、dthedifferencewasstatisticallysignificant(x2二1.014，P二0.000)，andtheosseousmetastasistimewasIongerforfourmonthsthanthatinthecontrolgroup,andthedifferencesintheosseousmetastasistimeandincidencerateofosseousmetastasisbetweenthetwogroupswerestatisticallysignificant
