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1、嘎木朱尔妇康片剂局部用药的毒性研究2009年8月第8期中国民族医药杂志53刺老苞根皮黄酮化合物处理的各组细胞RANK基因表达水平均有所上调,口呈现一定的量效关系•这些结果均初步表明刺老苞根皮黄酮化合物在体外可以有效地抑制破骨细胞的形成与分化，有助于延缓骨吸收过程，但其中作用机制述需要进一步深入的研究.参考文献[1]邵兴,赵敬华•浅析自然地理环境与土家族医药学的关系[J]•中国民族民间医药,2007,11(3):58—60・[2]方志先，赵晖，赵敬华.土家族药物志[M].第一版，中国医药科技出版社,2o07
2、:830—835.,[3]李永恕.土家族民间医药治疗骨病骨伤经验[J].屮国民族医药杂志,2001,7(3):57—59.[4]马静波.骨质疏松症的治疗和预防概述[J]•医师进修杂志,2005,28(5):9—11.[5]YasudaH.ShimaN.Anovelmolecularmechanismmodulatingosteoclastdifferentiatiionandfunction(J].Bone,l999,25(6):109—133.[6]KumedaYJnabaM,NishizawaYSec
3、ondaryosteoporosisanditstreatmentdiabetesMeUitus[J].NipponRinshoJ99&56(6):1579—1582.2009年5月6日收稿EffectofAraliaechinocaulisHand.MazzflavonoidsonthedifferentiationofosteoclastinducedfrombonemarrowinmicePEILingpeng,YInXia2,DongFuhui(l.CentralMINZUUniversityJn
4、stituteofMinarityTraditionalMedicineResearch,Beijing1000819China;2.ChinaAcademyofChineseMedicalSciences^WangjingHospitalJnstituteofOrthopaedicsandTraumatology)AbstractObjective:EffectofAraliaechinocaulisH.and.Mazzflavonoidsonthedifferentiationofosteoelast
5、inducedfrombonemarrowvitro.Methods:Mononuclearcellsofmacebone/nalTOWwereincubatedwitllDMEMcontainingmac.rephagecolonystimulatingfactor(M—CSF)andreceptoractivatorof7W一曲ligand(RAN~).l1leculturewastreatedwithAraliaechinocaulisHand.Mazzflavon6idsofdifferentco
6、ncentrations(10~mol?L,10moJ.L,J()〜mO卜L).Onthe7d,theculturecellswerefixedandwerestainedfortartate—resistantacidphossphatase(TRAP).Thefor一mationofosteoelastsWasquantifiedbycountingthenumberofTRAPmuhinuelearceils.11activityandtheex一pressionofreceptoractivato
7、rofNF一KB(RANK)mRNA.Results:TheappearanceofreducedmiceosteoclastsWas帅一ical.Comparedwiththecontrolgroup.thenumberofTRAPmuhinuclearcellsandTRAPactivityofAraliaechino.caulisHand.Mazzflavonoidsmiddle一dosegroupandhigh一dosegroupsignificantlydecreased(P<O・O5)・
8、ButtheexpressionofRANKmRNAsignificantlyincreased(P<0.05)bytreatedindifferentdoseAraliaechinocaulisHand.Mazzflavonoids.Conciusion:AraliaechinocaulisHand.Mazzflavonoidscaninhibitosteoclastsdifferentiationvitro.Keyw
