阜阳市婴幼儿卡介菌纯蛋白衍生物试验结果分析20141128001

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1、安徽阜阳市婴幼儿卡介菌纯蛋白衍生物试验结果分析赵仲达，徐海洋，孙良，蒋晓东，万俊峰，杜杰（阜阳市疾病预防控制中心，安徽阜阳236030）【摘要】目的了解儿童卡介苗（BacilleCalmette-Guerin,BCG）免疫后的阳性率水平及其影响因素，促进免疫规划工作稳步开展。方法用卡介菌纯蛋白衍生物(Card ofpurifiedproteinderivative ofBCG,BCG－PPD)试验方法，随机调查2919名儿童接种BCG3个月后的阳性率。结果BCG-PPD试验总阳性率90.89%，城区儿童阳性率高于农村儿童，城区男孩阳性率高于农村儿童。阜阳市辖区内8个县（市、区）中的界首

2、市阳性率高于全市平均水平，颍东区、颍泉区、太和县低于全市平均水平。出生当天接种BCG与出生30天后接种的阳性率较总体无差别；90天以内接种BCG阳性率高于出生90天以后接种的阳性率。卡痕大小与阳性率呈正相关，接种时间间隔与阳性率呈负相关。结论卡痕可作为BCG接种质量的参考依据。严把产科接种单位BCG接种关口，提高BCG接种及时率。进一步加强预防接种的培训和督导，规范接种操作，提高预防接种质量。【关键词】卡介菌纯蛋白衍生物试验；阳性率；预防接种质量Analysis ontheresultsofBCG purifiedproteinderivative testininfantsofFuy

3、angCityZhaoZhongda, XuHaiyang, SunLiang, etal(FuyangCenterforDiseaseControlandPrevention,Fuyang236030,China)[Abstract]ObjectiveTounderstandBacillusCalmetteGuerin（BCG）vaccinationqualityandimpactfactorssoastopromotesafeandeffectivevaccination.Method2919ofthevaccinatedchildrenwereselectedrandomly,a

4、ndtoconductthesurveyofseroconversionafterBCGvaccinationfor3monthsbyPurifiedProteinDerivativeofBCG（BCG-PPD）testmethod.ResultBCG -PPD test positivetransferratewas90.89%;urbanchildrenpositiveconversionrate washigherthan ruralchildren; urban boypositiverate washigherthan ruralchildren. Thepositivera

5、te of Jieshouwashigherthantheaveragelevel, whileYingdongDistrict, YingquanDistrictandTaiheCountywere lowerthantheaverage. NosignificantdifferencewasfoundforthepositiveratesbetweenBCGvaccination timeatbirth,after30daysand overall seroconversion,whereasthe8BCGpositive rateforBCGvaccination timewit

6、hin90dayswashigherthanthatof 90dayslater. ThesizeofBCG-PPDwaspositivelycorrelatedwiththetestpositiverate,whereasthetimeintervalbetweenbirthandBCGvaccinationwasnegativelycorrelatedwiththetestpositiverate.ConclusionA card markcanbe asthe referencebasisoftheBCG vaccinationquality.BCGvaccinationinob

7、stetric unitsshouldbecarefullywatchedto improveBCG timelyvaccinationrate. Furtherstrengthenthe trainingandsupervisionof vaccination, standardvaccination operationsoastoimprove thequalityofvaccination.为了解卡介苗（BacilleCalmette-G