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1、Proc.Natl.Acad.Sci.USAVol.93,pp.11219-11224,October1996NeurobiologyInductionofaphysiologicalmemoryinthecerebralcortexbystimulationofthenucleusbasalis(receptivefieldplasticity/auditorycortex/associativelearning)JONATHANS.BAKIN*ANDNORMANM.WEINBERGERtDep
2、artmentofPsychobiologyandCenterfortheNeurobiologyofLearningandMemory,UniversityofCalifornia,IrvineCA92717-3800CommunicatedbyJamesL.McGaugh,UniversityofCalifornia,Irvine,CA,Juen20,1996(receivedforreviewJanuary29,1996)ABSTRACTAuditorycorticalreceptivefi
3、eldplasticityThecharacteristicsoflearning-inducedRFplasticityhaveproducedduringbehaviorallearningmaybeconsideredtoproventobestrikinglysimilartothecharacteristicsofatleastconstitute"physiologicalmemory"becauseithasmajorchar-someformsofmemory.RFplastici
4、tyis(i)associative(requiresacteristicsofbehavioralmemory:associativity,specificity,stimuluspairing),(ii)highlyspecific(canbelimitedtotheCS+rapidacquisition,andlong-termretention.Toinvestigatefrequency±0.05octaves),(iii)discriminative(facilitationofbas
5、alforebrainmechanismsinreceptivefieldplasticity,wetheCS+frequencybutdepressionofanonreinforcedCS-pairedatonewithstimulationofthenucleusbasalis,themainfrequency),(iv)developsveryrapidly(fivetrialsorless),andsubcorticalsourceofcorticalacetylcholine,inth
6、eadult(v)islonglasting(retainedfor8weeks,thelongestintervalguineapig.Nucleusbasalisstimulationproducedelectroen-studied)(24-27).Therefore,werefertoitas"physiologicalcephalogramdesynchronizationthatwasblockedbysystemicmemory,"todistinguishitfromtheactu
7、alcontentsofbehav-andcorticalatropine.Pairedtone/nucleusbasalisstimula-iorallydelineatedmemory.tion,butnotunpairedstimulation,inducedreceptivefieldThislearning-inducedRFplasticityinvolvesspecificcorticalplasticitysimilartothatproducedbybehaviorallearn
8、ing.mechanisms,asthemajorsubcorticalsourceoffrequency-Thuspairedactivationofthenucleusbasalisissufficienttospecificinputtotheauditorycortex,theventralmedialinducereceptivefieldplasticity,possiblyviacholinergicac-geniculatenucleusofthethalamus,
