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1、REVIEWSClickChemistry:DiverseChemicalFunctionfromaFewGoodReactionsHartmuthC.Kolb,M.G.Finn,andK.BarrySharpless*DedicatedtoProfessorDanielS.KempExaminationofnature sfavoritemol-thesecrucialmoleculesaremadeeachdefined,enabled,andconstrainedbyaeculesrevealsastrikingpreferenceforcontain,atmo
2、st,sixcontiguousCÿChandfulofnearlyperfectªspring-load-makingcarbon±heteroatombondsbonds,exceptforthethreearomaticedºreactions.Thestringentcriteriaforovercarbon±carbonbondsÐsurelyaminoacids.Takingourcuefromaprocesstoearnclickchemistrystatusnosurprisegiventhatcarbondioxidenature sapproach
3、,weaddressherearedescribedalongwithexamplesofisnature sstartingmaterialandthatthedevelopmentofasetofpowerful,themolecularframeworksthataremostreactionsareperformedinwater.highlyreliable,andselectivereactionseasilymadeusingthisspartan,butNucleicacids,proteins,andpolysac-fortherapidsynthe
4、sisofusefulnewpowerful,syntheticstrategy.charidesarecondensationpolymersofcompoundsandcombinatoriallibra-smallsubunitsstitchedtogetherbyriesthroughheteroatomlinksKeywords:combinatorialchemistry´carbon±heteroatombonds.Eventhe(CÿXÿC),anapproachwecallªclickdrugresearch´synthesisdesign´35or
5、sobuildingblocksfromwhichchemistryº.Clickchemistryisatoncewaterchemistry1.Introduction:catalystswhichpreventnature scarbonylchemistrybasedBeyondtheParadigmofCarbonylChemistrysynthesesfromcollapsingintochaos.Sincemanybiosyntheticpathwaysrequireauniqueenzymeforeachstep,theenzyme-LifeonEar
6、threquirestheconstructionofcarbon±carboncontrolstrategyrequiredaheavyinvestmentoftimeandbondsinanaqueousenvironment.Carbonyl(aldol)chemistryresourcesforcatalystdevelopment.Withafewbillionyearsisnature sprimaryengineofCÿCbondformation.Notonlyandaplanetatherdisposal,naturehashadbothtimean
7、ddotherequisitecarbonelectrophiles(carbonyls)andnucleo-resourcestospare,butwe,aschemistsonahumantimescale,philescoexistinwater,butwaterprovidestheperfectdonot.environmentforprotonshuttlingamongreactants,whichisNevertheless,carbonyl-basedreactionshavealwaysbeenrequiredforreversi
