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时间:2019-06-20
《曲安奈德与5-氟尿嘧啶联合应用在瘢痕疙瘩临床疗效的Meta分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、l294中国美容医学2013年6月第22卷第12期ChineseJournalofAestheticMedicinejun.2013.Vo1.22.No.12·论著·曲安奈德与5一氟尿嘧啶联合应用在瘢痕疙瘩临床疗效的Meta分析姚泉,马少林(新疆医科大学第一附属医院整形美容科新疆乌鲁木齐830054)[摘要]目的:~+-1-曲安奈德与5一氟尿嘧啶联合应用在治疗瘢痕疙瘩的临床疗效。方法:计算机检索Cochrane图书馆、Medline数据库、Wiley数据库、CNKI数据库及万方数据库,以“曲安奈德”、“5一氟尿嘧啶”
2、、“瘢痕疙瘩”为关键词,检索各自数据库自建库至2013年4月期间所有有关曲安奈德单独应用与5一氟尿嘧啶联合应用治疗瘢痕疙瘩的前瞻性随机对照试验,评价纳入研究的方法学质量并进行资料提取后,采用RevMan5.2软件进行Meta分析。结果:共纳入10个前瞻性随机对照试验,试验组曲安奈德与5一氟尿嘧啶联合应用517侧,对照组曲安奈德单独应用508例,一共包括1025例瘢痕疙瘩患者。Meta分析结果显示:试验组和对照组治疗有效率差异有统计学意义(P3、4、nolonewith5-FluorouracilintreatmentofpatientswithkeloidYAOQuan,MAShao—lin(DepartmentofPlasticandAestheticSurgery,theFirstAfiliatedHospitalofXinjiangMedicalUniversity,Wulumuqi830054,Xinjiang,China)Abstract:0bjectiveResearchonthecliniceffectualityofcombinationTri5、amcinoloneand5—-FluorouraciIonKeloid.MethodsWesearchedCochrane,Medline,Wiley,CNKlandWanFangDate.AIIresearcheswereupdatedonApril,2013.Randomiedcontrolledtrials(RCTS)oftheefectualityOfcombinationTriamcinoloneand5一FluorouracilonKeloid.Themet}1OdO10gjcaIqualityofth6、eincludedstudieswasevaluated。anddateanalyseswereperformedusingtheCochraneCotlaborationSsoftwareRevMan5.2.ResultsAtotaIof10RCTSinvolving1025patientswithkeloid,whichtheexperimentalgroupinclude517patientsandtheycombinationofTriamcinoloneand5一FluorouraciI.andthecon7、trolgroupinclude508patientsandtheytreatmentwithTriamcinolone.Adescriptiveanalysisoftheresultswaspresented:Comparedwiththeefectiverate,theexperimentalgroupandthecontrolgroupwerestatisticallysignificantdifference(P<0.00001),andtheexperimentalgroupbetterthanthecon8、trolgroup.Comparedwiththecurerate.theexperimentalgroupandthecontroIgroupwerestatisticallysignificantdiference(P<0.00001),andtheexperimentalgroupbetterthanthecontroIgroup.Com
3、4、nolonewith5-FluorouracilintreatmentofpatientswithkeloidYAOQuan,MAShao—lin(DepartmentofPlasticandAestheticSurgery,theFirstAfiliatedHospitalofXinjiangMedicalUniversity,Wulumuqi830054,Xinjiang,China)Abstract:0bjectiveResearchonthecliniceffectualityofcombinationTri5、amcinoloneand5—-FluorouraciIonKeloid.MethodsWesearchedCochrane,Medline,Wiley,CNKlandWanFangDate.AIIresearcheswereupdatedonApril,2013.Randomiedcontrolledtrials(RCTS)oftheefectualityOfcombinationTriamcinoloneand5一FluorouracilonKeloid.Themet}1OdO10gjcaIqualityofth6、eincludedstudieswasevaluated。anddateanalyseswereperformedusingtheCochraneCotlaborationSsoftwareRevMan5.2.ResultsAtotaIof10RCTSinvolving1025patientswithkeloid,whichtheexperimentalgroupinclude517patientsandtheycombinationofTriamcinoloneand5一FluorouraciI.andthecon7、trolgroupinclude508patientsandtheytreatmentwithTriamcinolone.Adescriptiveanalysisoftheresultswaspresented:Comparedwiththeefectiverate,theexperimentalgroupandthecontrolgroupwerestatisticallysignificantdifference(P<0.00001),andtheexperimentalgroupbetterthanthecon8、trolgroup.Comparedwiththecurerate.theexperimentalgroupandthecontroIgroupwerestatisticallysignificantdiference(P<0.00001),andtheexperimentalgroupbetterthanthecontroIgroup.Com
4、nolonewith5-FluorouracilintreatmentofpatientswithkeloidYAOQuan,MAShao—lin(DepartmentofPlasticandAestheticSurgery,theFirstAfiliatedHospitalofXinjiangMedicalUniversity,Wulumuqi830054,Xinjiang,China)Abstract:0bjectiveResearchonthecliniceffectualityofcombinationTri
5、amcinoloneand5—-FluorouraciIonKeloid.MethodsWesearchedCochrane,Medline,Wiley,CNKlandWanFangDate.AIIresearcheswereupdatedonApril,2013.Randomiedcontrolledtrials(RCTS)oftheefectualityOfcombinationTriamcinoloneand5一FluorouracilonKeloid.Themet}1OdO10gjcaIqualityofth
6、eincludedstudieswasevaluated。anddateanalyseswereperformedusingtheCochraneCotlaborationSsoftwareRevMan5.2.ResultsAtotaIof10RCTSinvolving1025patientswithkeloid,whichtheexperimentalgroupinclude517patientsandtheycombinationofTriamcinoloneand5一FluorouraciI.andthecon
7、trolgroupinclude508patientsandtheytreatmentwithTriamcinolone.Adescriptiveanalysisoftheresultswaspresented:Comparedwiththeefectiverate,theexperimentalgroupandthecontrolgroupwerestatisticallysignificantdifference(P<0.00001),andtheexperimentalgroupbetterthanthecon
8、trolgroup.Comparedwiththecurerate.theexperimentalgroupandthecontroIgroupwerestatisticallysignificantdiference(P<0.00001),andtheexperimentalgroupbetterthanthecontroIgroup.Com
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