地高辛治疗窗浓度的再探讨

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1、地高辛治疗窗浓度的再探讨1*11123司凯英,王守春,栾杰,高志刚,韩丽萍,肖艳(11黑龙江大庆龙南医院,大庆市163453;21广州军区广州总医院,广州市510010;31黑龙江大庆油田总医院,大庆市163000)+中图分类号R96913;R97211文献标识码A文章编号1001-0408(2005)14-1081-03摘要目的:探讨地高辛治疗慢性心力衰竭的血清治疗窗浓度范围。方法:将心力衰竭患者随机分成小剂量组和常规剂量组,分别给予小剂量和常规剂量地高辛治疗,采用荧光偏振免疫法测定地高辛血药浓度。结果:小剂量组有效率、无效率、中毒率分别为7119%、2119%

2、、613%,常规剂量组分别为6417%、1911%、1612%,2组有效率、无效率均无显著性差异(P>0105),中毒率小剂量组显著低于常规剂量组(P<0105);小剂量组地高辛有效、无效、中毒浓度分别为(0187±0141)、(0167±0134)、(1170±0148)μg/L,常规剂量组分别为(1111±0148)、(0171±0139)、(1169±0163)μg/L,2组地高辛无效浓度、中毒浓度均无显著性差异(P>0105),地高辛有效浓度小剂量组显著低于常规剂量组(P<0101)。结论:地高辛治疗慢性心力衰竭的血清治疗窗浓度范围以0150～1150μg

3、/L为宜。关键词地高辛;心力衰竭;药物监测;治疗窗DiscussiononTherapeuticWindowConcentrationofDigoxinSIKaiying,WANGShouchun,LUANJie,GAOZhigang(DaqingLongnanHospitalofHeilongjiangProvince,Daqing163453,China)HANLiping(GuangzhouGeneralHospital,GuangzhouMilitaryCommand,Guangzhou510010,China)XIAOYan(DaqingOilField

4、GeneralHospital,Daqing163000,China)ABSTRACTOBJECTIVE:Tostudythetherapeuticwindowconcentrationrangeofserumdigoxininthetreatmentofchroniccardiacfailure1METHODS:Patientswithchroniccardiacfailureweredividedintosmalldosegroupandroutinedosegroup,andadministeredrespectivelywithlowdosedigoxin

5、androutinedosedigoxin,theserumdigoxinconcentrationsinpa2tientsweredeterminedbyFPIA1RESULTS:Theeffectiverate,invalidrateandtoxicationratesofthelowdosedigoxingroupwere7119%,2119%and613%respectively,thosefortheroutinedosedigoxingroupwere6417%,1911%and1612%re2spectively,nosignificantdiffe

6、renceswerefoundineffectiveratesandtheinvalidratesbetween2groups(P>0105),thetoxi2cationrateofthelowdosegroupwaslowerthanthatoftheroutinegroup(P<0105);Theeffectiveconcentrationrange,invalidconcentrationrangeandthetoxicconcentrationrangeoflowdosedigoxingroupwere(0187±0141),(0167±0134)and

7、(1170±0148)μg/Lrespectively,andthosefortheroutinegroupwere(1111±0148),(0171±0139)and(1169±0163)μg/Lrespec2tively,nosignificantdifferenceswerefoundintheinvalidconcentrationandthetoxicationconcentrationbetweenthetwogroups(P>0105),theeffectiveconcentrationofthelowdosedigoxingroupwassigni

8、fican