小口径人工血管血液相容性

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1、万方数据中国组织工程研究与临床康复第J2眷第6期2008—02—05出版JournalofClinicalRehabilitativeTissueEngineeringResearchFebruary只2008V01．12．No．6小口径人工血管血液相容性☆欧阳晨曦1，李沁1，王维慈1，周飞2，徐卫林2，李文斌2Bloodcompatibilityofsmall-calibervasculargraftsOuyangChen-xil，LiQinl．WangWei·cil，ZhouFei2，XuWei—lin2，LiWen-bin2AbstractBACKGROUND：Atpresent,ab

2、reakthroughstudyhasbeenachievedforthebig—calibervasculargrafts．whichhavebeenwidelyappliedintheelinicalpractice．WhiJetherearcstillsomeunsolvedkeyproblemsinfieldoftIlesmall．caliber(1essthan6llnndiameter)vasculargrafts，suchasvascularembolismandhistocompatibility．whichobstructsthepracticaluseofsmall．ca

3、libervasculargrafts．OBJECTIVE：Tointroducethecurrentstudyofvasculargrafts，analyzetheproblemsofdesigningsmall-calibervasculargrafts，andexplainthemethodofenhancingbloodcompatibility．RETRIEVALSTRATEGY：Acomputer-basedsearchwasundertakeninWWW．cnki．netandMedline(www．pubmed．com)toidentifytheatticlesaboutth

4、ebloodcompatibilltyofsmall-calibervasculargraftbetweenJanuary1975andAugnst2007．witIlthekeywordsof”Vasculargrafts，Polyurethane，Bloodcompatibility”inChineseandEnglish．Aftertheprimarycheck，atotalof143articleswerecollected．including28Chineseonesand1l5Englishones．LITERATUREEVALUATIoN：Thetitlesandabstrac

5、tsweresoreenedpreliminarily．thentherewere54articlesexcludedduetounrelatedobjectivesand64atticlesdeletedduetorepeatedcontents．finally25literatureswereinvolvedintheanalysis，including13onesregardinganimalexperiments，andinvivo，exvivo，cytologicaltrials，12onesregardingreviews，commentariesandlectures．DATA

6、SYNTHESIS：O)Thematerialsforbloodvesselprosthesisalemaialydacron，polyteflnaturalsilkandsoon，whilepolyurethanewithgoodcompliance，abradability，elasticity．biocompatibilityandanfcoagulantproperty，hasgmnedmuchattraction．②Small．calibervasculargraftsaleabsentsintheantithromboticeffect,andmayresultinvascula

7、rocclusionofgraftsthroughmuralthrombosisoccurredinlumenofbloodvessel，whichinducesthebloodcoagulationhyperfunction．slowsthebloodflow，andthickensthrombuslayer．③Asforthebloodcompatibility，山erearemanystudiesabo