资源描述：
《molecular epidemiology and evolution in an outbreak of fulminant hepatitis b virus》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、JOURNALOFCLINICALMICROBIOLOGY,Apr.2006,p.12881294Vol.44,No.40095-1137/06/$08.000doi:10.1128/JCM.44.4.12881294.2006Copyright©2006,AmericanSocietyforMicrobiology.AllRightsReserved.MolecularEpidemiologyandEvolutioninanOutbreakofFulminantHepatitisBVirus1121MariaAlmaBracho,Marı´aJ
2、ose´Gosalbes,FranciscoGonza´lez,Andre´sMoya,1andFernandoGonza´lez-Candelas*InstitutCavanillesdeBiodiversitatiBiologı´aEvolutivaandDepartamentdeGene`tica,UniversitatdeVale`ncia,46071Vale`ncia,12Spain,andDireccio´nGeneraldeSaludPu´blica,ConselleriadeSanitatiConsum,MicerMasco´26,
3、46010Vale`ncia,SpainReceived27July2005/Returnedformodification14October2005/Accepted31January2006InordertoestablishthetransmissionpathwayfortwooutbreakpatientsaffectedbyfulminanthepatitisB(FHB)followingasharedperiodofhospitalization,wesequencedthecompletegenomesofthehepatitisBv
4、iruses(HBV)isolatedfromthemaswellasfromthesuspectedcommonsourceand11additionalcontrols.PhylogeneticandstatisticalanalysesofthesesequencesrevealedthatthetwoFHBpatientswereindeedinfectedbyacommonsourceandthatthefataldevelopmentofthediseasedidnotappeartobeassociatedwithDownloaded
5、fromanymutationpreviouslyreportedtoberelatedtoFHB.ThesedatahavealsoallowedustoestimatetheextentanddistributionofgeneticvariabilityalongthegenomesofHBVgenotypeDsamplesfromthesamesourcepopulation.Asaresultoftheseanalyses,weprovideanimprovedstatisticalmethodtoindividualizetheassi
6、gnmentofeachsuspectedpatientandthesourceofanoutbreakandinformationonwhichgenomeregiontoanalyzeinthemolecularepidemiologicalassessmentofhepatitisBvirustransmissioncases.jcm.asm.orgHepatitisBvirus(HBV),theprototypememberoftheHe-representativeportionoftheHBVgenome.However,thereis
7、padnaviridaefamily,causesacuteandchronicliverdisease,noconsensusonthebestchoiceofregionforthiskindofchronicallyinfectingmorethan400millionpeopleworldwide,analysis.Severalauthorshaveusedthecoreregion(11,38),withanestimatedriskofdeathof25%forchronicallyinfectedothershaveemployed
8、theSregion(13),andmanyhaveusedatPennStateUnivonFebruary12,200
