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1、图1各组小鼠卵巢HE染色切片(HE,400×)A空白组;B模型组;C海参花水提物低剂量组;D海参花水提物中剂量组;E海参花水提物高剂量组;F阳性对照组Fig.1PhotographsonovarianbyH-Estaining(HE,400×)Acontrolgroup;Bmodelgroup;Clowdoseofwaterextractofseacucumberovumgroup;Dmiddledoseofwaterextractofseacucumberovumgroup;Ehighdoseofwat
2、erextractofseacucumberovumgroup;Fpositivedruggroup实验结果表明,海参花水提物能提高子宫、whichwasusedforthehealthfoodmaterials[J].QiluPharmAff(齐鲁药事),2011,30(6):346-348.卵巢脏器指数,增加子宫内膜厚度,同时也使卵[4]ZHAOHX,ZHOUDY,QINL.Optimizationofthe巢发育良好、卵泡数量增多,并且在一定程度上enzymatichydrolysisofseacucumberovum
3、withresponsesurfacemethod[J].FoodMachin(食品与机械),2010,26(5):提高了血清中雌二醇、孕酮含量。子宫、卵巢脏114-117.器指数是评价受试物雌激素效应的常用指标,均[5]JIANGJF,HAOGL.Effectofthevanadiuminnutrition[J].与体内雌激素水平呈正相关。通过卵巢切片发现FeedInd(饲料工业),2004,25(6):29-32.[6]LEXY,XUZX,SHILS.Effectsofsepiainkpoly-卵泡发育较模型组明显增强,提
4、示海参花水提物saccharidesonspermatogensisinjuredbycyclophosphamide对减缓卵巢功能的衰退有一定作用。血清检测显[J].ChinJMarDrugs(中国海洋药物),2012,31(5):23-26.[7]LIUHZ,WANGG,WUJL,etal.Amelioratoryeffectsof示,与模型组相比,海参花提取物能显著提高血sepiainkpolysaccharidesonpartialinternalorgansinjuriedby清中雌二醇及孕酮含量,也在一定程度上显示
5、了cyclophosphamide[J].ChinJModApplPharm(中国现代应用药学),2012,29(2):89-93.海参花水提物的雌激素样作用。[8]FANGL,WEIXH,HEQJ.Studiesontreatmentof在本次实验中,发现海参花水提物能改善雌性menopausalsyndromewithangengcapsules[J].ChinPharmJ(中国药学杂志),2006,41(22):1741-1744.小鼠POF、保护小鼠生殖系统,但是关于海参花的[9]MIAOMS.Experimental
6、AnimalsandAnimalExperimental有效组分及其作用机制,有待于进一步的研究。Techniques(实验动物和动物实验技术)[M].Beijing:ChineseMedicalPress,1997:145.REFERENCES[10]WANGF,ZHANGYH,ZUODY.EffectsofHongrenguicapsulesonmouseclimactericsyndromemodels[J].JShenyang[1]JIANGJ,YANGBL,TAIY.StudiesonresourcesandPhar
7、mUniv(沈阳药科大学学报),2008,25(7):581-585.bioactivesubstancesofseacucumber[J].LettBiotechnol(生[11]CHENL,ZHANGT,CHENJG.Studyontheeffectof物技术通报),2004,15(5):537-540.Gengningpillsonperimenopausalsyndromeinrats[J].ChinJ[2]ZHAOQ,WANGJF,XUER.ComparativestudyontheHospPharm(中国医院药学杂
8、志),2012,32(11):856-858.componentsandimmunefunctionofthreespeciesofsea[12]LIJ,LINLW,XINQ.Anti-agingeffectofgreenteacucumber[J].JFishSciChin