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《局部定向抗结核药物缓释材料在兔体内的评价分析-(5801)》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、中文摘要INH-RFP-PLGA-β-TCP该材料可以很好的修复兔的桡骨缺损，材料中的抗结核药物对兔的桡骨缺损的修复作用无严重影响，材料中的抗结核药物可以长时间稳定释放并在局部保持杀菌浓度。关键词：抗结核药物；聚乳酸-羟基乙酸聚合物；β-磷酸三钙；药物缓释代骨材料；骨修复3万方数据英文摘要EVALUATIONOFANTI-TBDRUGDELIVERYMATERIALSLOCALLYORIENTEDINRABBITABSTRACTTuberculosishasinfluencedpeople'shealthandqualityoflifeforlongti
2、me.Inadditiontothesurroundinglymphnodesaroundoutsidethenucleus,boneandjointtuberculosisisthemostcommonextrapulmonarytuberculosis,accountingforabout3%oftuberculosis.Thetraditionaloralanti-TBdrugsisdifficulttoachievethedesireddrugconcentrationinthetumorregion,becauseofboneandjointt
3、uberculosislesionsparticularityanditisliabletoleadtoaseriesofsideeffects.Tosolvetheproblems,amethodoflocaltreatmentofbonetuberculosisdrugisintroduced.Peoplesolvethespinaltuberculosisremoveboneformationaftermultipledefectswithautologousboneallograftboneandartificialboneasrepairmat
4、erialsnow.Autologousboneandallograftboneareunabletoreceivealargenumberofanti-tuberculosisdrugs,sotheartificialboneiswidelyusedaslocalsustainedreleasecarrier.PLGAhasadvantagesoflargerdrugloadings,long-termdrugrelease,adjustabledegradationtime.Theβ-TCPhasgoodbiocompatibility,andbio
5、degradation.Itcanprovideboneformationwithelementssuchascalciumduringthedegradation.TheexperimentistojoinINHandRFPintothePLGAandβ-TCPmaterials,thenobserveitsroleintherepairofrabbitradialdefect.1.SyntheticofINH-RFP-PLGA-β-TCPmedicineslowreleasematerialsWedissolvesPLGAincertainamoun
6、tof1,4-2oxygensulfurring,anddividedtheappropriatesolutionaveragePLGAfullydissolvedsolutionintofourgroups,accordingtothecontentofPLGAtakecorrespondingβ-TCP.Accordingtopredetermineddrug-polymerinteractionstakeINHandRFPpowder,fourgroupsofsolution,respectivelyarejoinedintothe4万方数据英文摘
7、要β-TCP,betaTCPandINHpowder,betaTCPandRFPpowderandbetaTCP,INHandRFPpowder.Ultrasonicblending,thesuspensionliquidisputintoamould,thenisfrozenfor2hoursat-4℃,-20℃and-80℃successively.Putthemouldinthelyophilizerfreezeanddryfor72hours.2、Theresultingmaterialwasfrozenforlateruse.Rabbitfor
8、synthesizingofthedistalradiusbonedefects
