急性脑梗死患者尿na+,尿类洋地黄物质与红细胞内na+,mg2+浓度及atp酶的相关性

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1、维普资讯http://www.cqvip.com·260·CllnNeurol。Oct0b盯2∞3。Vo1．16。No．5·论著·急性脑梗死患者尿Na+、尿类洋地黄物质与红细胞内Na+、Mg2+浓度及ATP酶的相关性孙萍袁林苗蓁蓁杜立朱成章【摘要】目的探讨急性脑梗死(ACI)患者尿Na、尿类洋地黄物质的改变及与红细胞内Na、M浓度和红细胞膜ATP酶活性的相互关系。方法检测35例ACI患者尿Na、尿类洋地黄物质含量和血红细胞膜A11P酶活力。血红细胞内Na、Mg的浓度。并与正常对照组比较。结果ACI患者尿Na、尿类

2、洋地黄物质的浓度、血红细胞内Na浓度明显高于对照组(P<0．05，P<0．001，P<0．01)，红细胞内M浓度较对照组降低(P<0．05)，红细胞膜A11P酶活性较对照组降低(P<0．05一P<0．01)，尿Na与尿类洋地黄物质呈正相关，红细胞内Na与尿Na、尿类洋地黄物质呈正相关。与A11P酶呈负相关，红细胞内M与尿Na、尿类洋地黄物质呈负相关，与A11P酶呈正相关。结论ACI患者存在类洋地黄物质的异常分泌、尿Na排泄增加以及红细胞膜受体功能受损。【关t词】急性脑梗死尿Na尿类洋地黄物质红细胞Na、Mg2A1

3、1P酶【中圈分类号】R743．32【文献标识码】A【文章编号】1004．1648(2003)05．(Y260-03Theeat'relationbetweenurinenatriumandurineEng0ge帅lls．Digitalis．m【e翻Ib嘲懈，VelltB朗．ythr町q，te岫trt哪antimagnesiumandadenosinetriphosphateenxymeinpatientswithSterilecerebral

4、I嵋InSunPing；YuanLin，MiaoZhenzhen，et

5、a1．DepartmentofNurology，GuiyangNenropathicHospital，Guiyang550005，China【Abstract】ObjectiveToinvestigatethecorrelationbetweenlevelsoferythrocytenatrium(EN)，magnesium(EM)，adenosinetriphosphateenzyme(Na-KATPase，Ca2-Mg2-ATPase)activityvelt~USurinenatrium(UN)，urine

6、endogenousdigitalis-likesubstances(UEDLS)changeinpatientswithacutecerebralinfarction(ACI)．Methods35patientswithAC1weremeasuredinUEDLS，thechangesofUN，erythrocytemembraneATPaseacti~,ity，andlevelsEN，EM，andcomparedwiththenormalcontrols．ResultsLevelsofUN，UEDLS，ENw

7、eresignificantlyelevated(P<0．05。P<0．001，P<0．01)。EMWassignificantlyreduced(P<0．05)，erythcocytemembFaneATPaseactivitywassignificantlylowerinacuteCIgroupthanthoseinthenormalcontrols(P<0．05～P<0．01)．TheEN，UNweresignificantlypositivelycorrelatedwithEdls．TheEN，UN，ED

8、LSwerenegativelysignificantlycorrelatedwitherythrocytemembraneATPaseactivity，theEMw聃positivelysignificantlycorrelatedwitherythrocytemembranceATPaseactivity．ConclusionACIpatientshaveexistedabnormalitysecretionofEDLS，UNexcreteincrease，erythrocytemembrandrecepto

9、rfunctiondamage．【Keywords】AcutecerebralinfarectionVersusurinenatriumUrineendogenousdigitalis-likesubstancesErythrocytermtriumandmagnesiumATPase为进一步从病理生理及细胞水平研究急性脑梗均经头部CT或MRI确诊。肝肾功能均正常，均无心