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1、汉防己甲素与克矽平联合治疗矽肺远期疗效观察116?环境与职业医学2002年4月第】9卷第2期ChinJEnvinmOccIMed.Apr2O02Vot19No2文章编号:1006-3617t2002)ff2-011604中国分类号:R1352文献标识码:A汉防己甲素与克矽平联合治疗矽肺远期疗效观察【职业病防治】周泽深，王飞云•胡一本,孙垒礼，孙文澈•彭娟娟，闻军湖天锡，李学祯.蔡铁安，谷圣常摘要:［目的］病人按国家,，八?五^课题《矽肺治疗措施及鼓果评伊研究》的汉防己甲素和克矽平联合沿疔矽肺的的继续治疗观察•［结果］垒量组和维量组的症状好转率较停药组和对照组高，尤其是呼吸困难症
2、状・X线胸片垒量组有明显好转病例2饵，有进展的病例也较其他组少•好转病例仍集中在过去接触高浓度矽尘的病例•停药后病变出现反跳的经继续用药,可好转•不良反应较轻•［结论］汉防已甲素和克矽平联合用药治疗矽肺口」提高疗效，降低不良反应.关键词:矽肺;汉防己甲素;克矽平TheLong.termEffectsofCmnbinafionTherapywithTetrandrineandPVNOinSi吐00sisPa6虫血bZHOUZe-sheWANGFei・)v〜・x,HUY〜・ben,SUNjin—SL〜，VWen—h,w,PENGJ㈣俩,WENHUTian-xi12Xue一:,C
3、AlTie・an,GUSheng・clumg(l.ShonghaiOccupationalDiseaseHosphal,翰咄200433,Chi—w:2」z=hongMaa〜urgicdMiningCompanyHospita1)Abstr-t:[Objective]St^dDng】elong一termourativeeffectsOllthesilicosispatientstreatedpr-,iouslyfirstinaccordingtothenationar,8?15,,p,-vayi.gOHTherapyOdandCurativeEffectsfarSilicosi
4、sofCombiaationTherapywithtetran&ine(Tr)and一yy缸e-ill(PO)fortwoyears,thenstop#,tgtherapyforoIleyeararidthencontinueingtherapyagain[Methods]Allthesepfilbweredi〜ddedintofourgi'oupsaccaMingtothechestX・rayi'esult:(!)off,haldOsgegroup:TT200ms/day,6daysperweek;l%P-q9qO144mlwasdintobronchithrough
5、fibrobmnchiendoscopetorlp〜・ayear.@conliauousdOsage〜cmp:7T'1OOmg3timesperday,onedayperweek③therapy-ceasedgrouparm④contmlgroup;take4placebotablets,or.ceaweek.Acoui^S〜oftreat—merittakesthreemonthsandwithOrle・IIin〜'valhetweentwocaIIses,alltogethersixCOlllr〜scairiedoutduringtwoyeatsJResvl〜]Itwtth
6、igherthatthesymptomsmendedinthe胁andsecondgroup.especiallyfdrthesymptomofd）qmooTherewassignificantim—plw.,emertto/lchestX-rayfilmf2easesinthefirst肿up.Numberofca,,a-s-,Sthadvarcingofdiseaseinthefirstgrouparelessthanthatinocherthreegroups.Improvedcaseswereconcentratedinheavilyexp,,〜edgroup.Pati
7、ent^conditionwasimprovedaftermedicaltherapy_n,ifhisconditionwasrebourdafterinterruptedtherapy.ThesideeffectandtoxicityOfthiskindoftherapyisb!ll・【Con，ell摩bn]Tetrandrineand/z,rb-oincOn砌ti帅forsL!ieo〜isthera〜rhavebetterceffectsandhadve/〜effev/s・KeyWord
