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1、安度更年汤对围绝经期雌性大鼠雌二醇、骨代谢干预的实验研究3血清雌二醇的含量与骨密度及骨矿含量呈正相关，与血清骨钙素呈负相关。4经安度更年汤治疗后的大鼠卵巢内各级卵泡数目及卵泡液少，形态与模型对照组接近。结论安度更年汤能提高围绝经期雌性大鼠血清E2的水平，降低血清BGP的水平，增加大鼠骨密度及骨矿含量，但对大鼠卵巢的组织形态改善无显著影响。其作用机理可能与安度更年汤具有类雌激素样作用，抑制破骨细胞活性，抑制骨吸收，降低骨转换，减少骨量丢失有关，从而早期干预围绝经期骨代谢，预防绝经后骨质疏松的发生。关键词安度更年汤围绝经期骨质疏松骨代谢2摘要Interventio
2、nofAndugengniantangontheseraestradiolandbonemetabolisminperimenopausalfemaleratsRenYaPing(GynecologyofTCM)DirectedbyZhangXiaoDanAbstractObjectiveChinesemedicineAndugengniantang(ADGNT)onthetreatmentofperimenopausalsyndromemechanismandonbonemetabolisminperimenopausalinterventionmechan
3、ism.Thesubjectofanimalexperiment;bytheratswasmeasuredbyradioimmunoassayofserumestradiol(E2)levels,osteocalcin(BGP)content,measuredbydualenergyX-measuredbonemineraldensity(BMD),bonemineralcontent(BMC)，afterpathologysectionoftheovariantouseopticalmicroscopyitspathologicalchanges.Tocle
4、arAndugengniantang(ADGNT)onperimenopausemodelinrats,andestrogenlevelsandbonemetabolisminperimenopausalrelevance.FurtherevidencethatADGNThasaclearyinblood,bonehealthroleofgluten,andtoimprovebonemetabolisminperimenopausalandearlypostmenopausalwomentopreventosteoporosis,fortheChineseme
5、dicinetreatmentoffemaleclimactericsyndromeprovideanimalexperimentalevidence.Method12-month-oldfemaleSDratsofcleangrade,50,3monthsoldfemaleSDratsofcleangradeyouth,10.12montholdratsfor10daysVaginalcytology,whoshowedirregularestrouscycle,thatis,themodelwassuccessfulperimenopause.40rats
6、wererandomlydividedinto4groups:modelcontrol(MC);Jixicifencontrol(JXCFC),low-dosageADGNTcontrol(LADGNTC),high-dosageADGNTcontrol(HADGNTC),Withtheyouthgroup（YC）atotalof5groups，eachwith10.Controlgroupandyouthgroupsweregivennormal-1-1saline10ml·kg·dorally,MCandYCwereperfusedwithnormalsa
7、line10ml·kg·d-1-1-1orally,JXCFCweregiven0.08mg·kg·d,HADGNTCandLADGNTCweregiven-1-1-1-159g·kg·d、29.5g·kg·d、theabovefivegroupsaccordingtotheamountofdruginratsandtheweightequivalentgavage.weighingonceaweek,fromthemodelwas3安度更年汤对围绝经期雌性大鼠雌二醇、骨代谢干预的实验研究successfuladministrationof1day,daily
8、gavage2consecutive3
