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ID:32864116
大小:1.32 MB
页数:38页
时间:2019-02-16
《卡马西平及奥卡西平对成人癫痫患者血管疾病危险因素的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、南昌大学硕士学位论文卡马西平及奥卡西平对成人癫痫患者血管疾病危险因素的影响姓名:陈夏申请学位级别:硕士专业:神经病学指导教师:张明201206摘要目的:探讨卡马西平(carbamazepine,cBz)及奥卡西平(oxcarbazepine,OXC)单药治疗对成人癫痫患者血管疾病相关危险因素的影响。方法:采用前瞻性研究,选择71例新诊断的成人癫痫患者为实验组,根据患者一般情况分别选用CBZ单药治疗(CBZ治疗组,n-35)及OXC单药治疗(OXC治疗组,n=36)。治疗前,检测实验组身体质量指数(bodym
2、assindex,BMI)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL.C)、低密度脂蛋白胆固醇(LDL.C)、脂蛋白a(LPa)、同型半胱氨酸(homocysteine,Hey)、C反应蛋白(C.reactiveprotein,CRP)及尿酸水平,并与74例健康对照进行比较;单药治疗6个月后,再次检测实验组上述指标,分别与治疗前进行比较,同时将CBZ及OXC治疗组的检测指标在两组间进行比较;分别将病程、发作类型及药物剂量等因素与上述各检测指标进行多元回归分析。结果:实验组与对照组在
3、性别、年龄、BMI及平均脂肪摄入量方面无统计学差异。在血管疾病危险因素的比较方面:1.药物治疗前,实验组与对照组间TC、TG、HDL.C、LDL.C、LP(a)、Hcy、CRP及尿酸水平无显著差异(P>0.05)。2.CBZ治疗组中,治疗后与治疗前相比,血脂指标TC、LDL—C、LP(a)升高,且Hcy及CRP水平升高,差异均有统计学意义(P<0.05),尿酸水平治疗前后无差异。OXC治疗组中,治疗后Hey水平较治疗前升高(P4、CBZ治疗组治疗后TC及CRP水平显著高于OXC治疗组(P<0.05)3.多元逐步回归分析筛选出性别及药物剂量两个相关因素,TC水平与性别显著相关,Hcy水平与OXC剂量显著相关。结论:癫痫部分性发作本身对血管疾病危险因素无显著影响。CBZ可导致血脂、Hcy及CRP水平升高,OXC可导致Hcy水平升高,两种药物对尿酸水平均无影响。CBZ较OXC对血脂及CRP的影响更大。OXC治疗的癫痫患者Hcy水平随着剂量的增多而增高。关键词:卡马西平;奥卡西平;血脂;血管危险因素AbstractABSTRACTobjec5、tiveToevaluatetheeffectsofcarbamazepine(CBZ)andoxcarbazepine(oxc)monotherapyonvascularriskfactorsinadultswithepilepsy.MethodsThisclinicaltrialwasaprospectivestudy,71newlydiagnosedadultpatientswithepilepsywereenrolledinthisstudyastrailgroup,selectCBZmonothe6、rapy(CBZtreatmentgroup,n=35)andOXCmonotherapy(OXCtreatment.n=36)accordingtotheindividualbasicsituation.Beforetreatment,bodymassindex(BMI),plasmaTC,TGLDL—C,HDL-C,LP(a),homocysteine(Hcy),C.reactiveprotein(CRP)anduricacidlevelsweremeasuredinthetrailgroupandco7、mparedthemwith74controls;Theindicatorsabove-mentionedweremearsuredagainafter6monthsmonotherapy,comparedthemwiththeindicatorsoftrailgroupbeforeinitiation,andthencomparedtheindicatorsbetweentwotreatmentgroup;Multpleregressionanalysiswereadoptedtodetecttherel8、ationshipbetweenindicatorsabove.mentionedandthefactorssuchasduring,seizuretypesanddoseResultsTherewerenostatisticallysignificantdifferencesingender,age,height,BMIandaveragefatintakebetweentrailgroupandcontrol
4、CBZ治疗组治疗后TC及CRP水平显著高于OXC治疗组(P<0.05)3.多元逐步回归分析筛选出性别及药物剂量两个相关因素,TC水平与性别显著相关,Hcy水平与OXC剂量显著相关。结论:癫痫部分性发作本身对血管疾病危险因素无显著影响。CBZ可导致血脂、Hcy及CRP水平升高,OXC可导致Hcy水平升高,两种药物对尿酸水平均无影响。CBZ较OXC对血脂及CRP的影响更大。OXC治疗的癫痫患者Hcy水平随着剂量的增多而增高。关键词:卡马西平;奥卡西平;血脂;血管危险因素AbstractABSTRACTobjec
5、tiveToevaluatetheeffectsofcarbamazepine(CBZ)andoxcarbazepine(oxc)monotherapyonvascularriskfactorsinadultswithepilepsy.MethodsThisclinicaltrialwasaprospectivestudy,71newlydiagnosedadultpatientswithepilepsywereenrolledinthisstudyastrailgroup,selectCBZmonothe
6、rapy(CBZtreatmentgroup,n=35)andOXCmonotherapy(OXCtreatment.n=36)accordingtotheindividualbasicsituation.Beforetreatment,bodymassindex(BMI),plasmaTC,TGLDL—C,HDL-C,LP(a),homocysteine(Hcy),C.reactiveprotein(CRP)anduricacidlevelsweremeasuredinthetrailgroupandco
7、mparedthemwith74controls;Theindicatorsabove-mentionedweremearsuredagainafter6monthsmonotherapy,comparedthemwiththeindicatorsoftrailgroupbeforeinitiation,andthencomparedtheindicatorsbetweentwotreatmentgroup;Multpleregressionanalysiswereadoptedtodetecttherel
8、ationshipbetweenindicatorsabove.mentionedandthefactorssuchasduring,seizuretypesanddoseResultsTherewerenostatisticallysignificantdifferencesingender,age,height,BMIandaveragefatintakebetweentrailgroupandcontrol
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