糖化血红蛋白和同型半胱氨酸联合检测在糖尿病微血管病变中的应用

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1、糖化血红蛋白和同型半胱氨酸联合检测在糖尿病微血管病变中的应用邓桔芳1邱芬芳1陈远东2黄友娜3(1惠州市屮心人民医院检验科516001)(2惠州市第三人民医院检验科516001)(3惠州市第二妇幼保健院检验科516001)【摘要】目的探讨糖化血红蛋白和同型半胱氨酸联合检测在糖尿病微血管病变屮的应用价值。方法选取80例2型糖尿病患者为研究对象，将该组患者按照血糖控制水平及是否合并有微血管病变分为A、B、C三组，A组血糖控制相对稳定未合并有微血管病变；B组血糖控制不佳未合并有微血管病变；C组血糖控制不佳合并有微血管病变。结果糖尿病组的HbAlc、Hey、PLT、PDW、MPV均显著高

2、于对照组,有统计学意义(P<0.05)o糖尿病C组的HbAlc.Hey、PLT、PDW、MPV均显著高于A组,有统计学意义(P<0.05)oB组的HbAlc、Hey、PLT、PDW、MPV均显著高于A组，有统计学意义(P<0.05)oC组的HbAlc、Hey、PLT显著高于B组，有统计学意义(P<0.05)o结论HbAlc和Hey可反映糖尿病微血管病变的严重程度，对糖尿病为血管病变的早期诊断具有重要的检测价值。【关键词】糖化血红蛋口同型半胱氨酸糖尿病微血管病变【屮图分类号】R446【文献标识码】A【文章编号】2095-1752(2014)04-0047-

3、02ApplicationofglycosylatedhemoglobinandhomocysteinedetectionindiabeticmicroangiopathyDengZhefang1QiufragrancelChenYuandong2HuangYouna31>DepartmentoftheCentralPeople'sHospitalofHuizhou5160012、Laboratoryofthethirdpeople'sHospitalofHuizhoucity5160013>DepartmentofHuizhoucitysecond516001【Abstrac

4、t]Objective:Toexploretheapplicationvalueofhomocysteineglycosylatedhemoglobinvalueofcombineddetectionofdiabeticmicroangiopathy.Method:eightypatientswithtype2diabetesforthestudy,ThegroupofpatientsaccordingtowhetherglycemiccontrolandassociatedwithmicrovasculardiseaseisdividedintoA,B,Cthreegroup

5、s,Arelativelystablebloodglucosecontrolisnotassociatedwithmicrovasculardisease;Bgroupisnotassociatedwithpoorglycemiccontrolmicrovasculardisease;groupCassociatedwithpoorglycemiccontrolmicroangiopathy.Results:lndiabeticgroupofHbAlc、Hey、PLT、PDW、MPVweresignificantlyhigher,withstatisticalsignifica

6、nce(P<0.05).lndiabeticgroupCofHbAlc>Hcy>PLT>PDW^MPVweresignificantlyhigherthangroupA,withstatisticalsignificance(P<0.05).lngroupBHbAlc,Hey,PJ,PDW,MPVweresign讦icantlyhigherthangroupA,withstatisticalsignificanee(P<0.05).lngroupCofCHbAlc、Hcy^PLTwassignificantlyhigherthangroupB,wasstat

7、isticallysignificant(P<0.05).Completion:HbAlcandHeymayreflecttheseverityofdiabeticmicroangiopathy,diabeteshasimportantvalueforthedetectionofearlydiagnosisofvasculardisease.【Keywords]glycosylatedhemoglobinhomocysteinediabetesmicrovasculardisease近