同型半胱氨酸与2型糖尿病微血管病变的相关性-研究

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1、山东省医学科学院硕f研究生学位论交结论：本资料发现DN、DR组患者血浆tHcy水平明显升高；高tHcy组的叫、DR发生率明显高于iF常tHcy组，提示tHcy水平与糖尿病所特有的微血管并发症的发生具相关性，Logistic回归分析结果进一步显示空腹高tHcy血症是糖尿病微血管病变的独立危险因素之一。本研究显示高tHcy组血清FA、VitB．，均明显降低，甲钻氨F预治疗后，血浆tHcy降低。提示VitB，：缺乏可能是诱发高they的一个重要因素。本研究尚显示高tHcy组Scr明显升高，提不肾小球滤过事降低也是诱发高tHcy的一个重要因素

2、，但糖尿病3组与c组中Scr水平并无锃著性差异，提不在Scr水平升高以前，糖尿病病人就存在tHcy水平的升高，高tHcy血症与糖尿病的代谢紊乱有关。本资料还发现糖尿病3组与C组相比FBG、flbAle、TG及SBP等明显升高，也提示高tHcy血症也是糖尿病代谢紊乱的表现。关键词：同型半胱氨酸2型糖尿病糖尿病‘肾病糖尿病视网膜病变4由东誊取擘转学筏壤{硪究皇警建论芟StudyontheRelationshipBetweenTotalFastingPlasmaHomocysteine(tHcy)andMicroangiopathyinTy

3、pe2DiabetesMellitus(蚤渺PostgraduateZouxiaohuiSupervisorProfWanxuguangABSTRACTBackgroundandobjactive：Hyperhomocysteinemiahasbeenregardedastoberelatedtoadversevasculareffectssuchascardiacsuddendeath，stroke．pulmomaryembolism，andsoon．Recentresearchrevealedthathyperhomocystei

4、nemiaisrelatedtomacroangiographyinpatientswithtypeIId{abetesmellitus(DM)，butits’relationshiPwithdiabeticmicroangiographyremainsuncertain．ThegoalofthisstudyiStOobservetherelationshipbetweenhyperhomocyseinemiaanddiabetesmel11tusandits’chroniccomplications，investigatetheco

5、rrelationbetweentotalfastingplasmahomocysteine(tHey)andmicroangiopathyandthefactorsinfluencingplasmatHeyinpatientswithDM．Inaddition，toestimatethetherapeuticeffectstolowertheplasmatHeylevelofVitamineB12administration．Methods：SeventysevencasesoftypeIDMandtwentyonecasesofn

6、ormalindividualswereenrolledinthestudy。Thecaseswithtype2DMweredividedintothreegroupaccordingtoUAMlevelandanophthalmoscopeexamination：(1)32cases(14male)withoutcompiications(NDCgroup)，withanmeanageof56．84years．(2)22cases(10male)complicatedwithretinopathy(DRgroup)。withanav

7、erageageof59．77years．(3>Anothergroupwithnephropathy(DNgroup)。withanaverageageof58．55years．21casesofhealthyindividualswereenrolledintocontrolgroup．ThehyperhomOcysteinemiapatientspickedoutfromthiscohortweredevidedintotwogroups：oneiscontrolgroup(C)administeredwithplacebo，t

8、heothergroupistreatedwithmecobalamine．Datusofsystolicbloodpressure(SBP)，diastolicbloodpressure(DBP)，fastingblo