乳腺癌x线征象与病理及分子亚型相关性的研究

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1、徐州医学院硕士学位论文papillarycarcinomawere3cases，themucinousadenocalcinomawere2Cases．(1)Mammographicfindingsforsimplemasswere51，characterizedbymasswithcalcificationwere48，simplecalcificationin36．Simplemass笛themainimageperformanceismedullaryearcmomas(I1／12)andmucinousadenocarcinoma(2／2)，therealesignificantd

2、ifferencestootherpathologicaltypeofbreastcancer．SimplecalcificationismostcommoninDCIS(20／24)．Therealesignificantdifferencestootherpathologicaltypeofbreastcancer．Masswithcalcifica石onismostcommonininvasiveductalcalcmoma(tDC)(46／89)，therearesignificantdifferencestootherpathologicaltypeofbreastcancer．

3、(2)135lesionsweredepartedintothreehistologicalgrade．Grade1：33cases，Grade2：76cases，Grade3：26caSes．Summarizingtheresultsofthenumbersandratiosofeachmammographicfindingaccordingtohistologicalgrade．Breastlumps，marginsandcalcificationrelation谢tllhistologicalgradehadstatisticalsigtfificance(r．--0．345，P=-

4、0．038；rn=0．340，P=0．045；rn=O．330，P--0．031)．DistributionofcalcificationofbreastcRIlcerassociatedwithhistologicalgradingrelationshiphasnostatisticalsignificance(h=o．285，P=0．133)．InGrade1tumors，significantdifferenceswerefoundbetween谢t11polymorphismandbranchcalcificationshape俨O．049)．InGrade2tumors．sign

5、ificantdifferenceswerefoundbetweenthosewithirregularandovalmargms俨0．014)．InGrade3tumors，significantdifferenceswerefoundbetweenthosewithirregularandlobulatedorovalmargins俨=0．008andP=O．011)，betweenthosewithspeculatedandlobulatedorindistinctperiphery(P=0．004andP=O．004)，betweenthosewitharod·likeandpol

6、ymorphismcalcificationshape(P=O．037)．(3)Resultsofimmunohistochemistry：In135lesions，87ERpositive，positiveexpressionrateof64．4％；79PRpositive，positiveexpressionrateof58。50％；83HER-2positive，positiveexpressionrateof61．50％；P53positivecaseswere64，positiveexpressionrateof47．40％；ERFRpositive25，positiveexpr

7、essionrateof18．50％，ThecorrelationsofBreastlumps，malgins，calcificationwithsubtypeswerestatisticallysignificant(r=-O．369，P<0．001；r=-0．278，P=O．005；r=-0．218，P=O．021)，Distilbutionofcalcificationofbreastcanccrassociate