ck7、ck8、ck14、ecadherin、αsma、s100、vimentin在涎腺多形性腺瘤中的表达

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1、大连医科大学硕士学位论文瘤性肌上皮细胞中表达程度不一致，提示其与正常的肌上皮细胞不同。关键词：多形性腺瘤角蛋白E．钙黏蛋白a—SMAS100波形蛋白2大连医科大学硕士学位论文ExpressionofCK7，CK8，CKl4，E—cadherin，伐一SMA，S100，⋯·●●l●l1●■●1Vimentininsalival’VglandDIeomorDnlCadenomaSMasterdegreecandidate：WangYuancaiSupervisor：ProfessorLiuTingji

2、aoMajor：BasicScienceofStomatologyAbstractObjectives：Pleomorphicadenoma(PA)isthemostcommonsalivaryglandtumorsintheoralandmaxillofacialregion．Itaccountsfor51％ofsalivaryglandtumorsandfor88％ofsalivaryglandbenigntumors．PAshowsagreatdegreeofmorphologicaldiv

3、ersity．111eessentialcellularcomponentsofPAareepithelialandmyoepithelialcells，andstromalcellsinmyxoidandcartilaginoustissues．ToinvestigatethedistributionanddifferentiationofmyoepithelialcellsinPA，weanalyzedtheexpressionofCK7，CK8，CK14，E-cadherin，0【一smoo

4、thmuscleactin(仅一SMA)，$100andVimentin(Vim)innormalsalivaryglandsandPAs．Materialsandmethods：TMsstudyincludes66casesofPAand44casesofnormalsalivaryglandsobtainedfromthefirstaffiliatedhospitalofDalianMedicalUniversity．Thesampleswerefixedandembeddedinparaff

5、in．andthenserialparaffinsections、Ⅳitll49mthicknesswereprepared．Immunohistochemicalstainingwasperformedonparaffinsectionsusingthestandardstreptavidin—biotincomplextechnique．Ineachcase，thepositiveimmunoreactionwithantibodiesagainstCK7，CK8，CKl4，E—cadheri

6、n，0【-SMA，S100andVimWasquantifiedbymeasuringtheintegratedopticaldensity(IOD)ofthedefinedfieldsusingIPP(Imagepm-plus)6．0software．TheSPSS16．0statisticalanalysissoftwareforWindowsWasusedforstatisticalanalysis．MannWhitneyUtestwasusedtoconfirmcomparisonsofb

7、inaryvariables．Statisticallysignificantdifferencewasdefinedasp

8、nPA，CK7，CK8andE-cadherinmainlyexpressedinluminalcells；CKl4，S100andVimmainlyexpressedinmostofmyoepithelialcells，and0【·SMAexpressedinmyoepithelialcellsindifferentdegrees．TheexpressionlevelofCK8，CKl4，0【-SMA，S100andViminPAWassignificantly3大连医科大学硕士