抑制核因子κb对急性血管性排斥反应的影响

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1、抑制核因子xB对急性血管性排斥反应的影响摘要B组为399．80士11．196％，两组比较有显著性差异(PO．05)。移植后各组CD80无表达，CD86的表达：C组33．

2、14±1．11％，D组13．26±0．67％，E组54．10±2．07％，F19．06±O．93％，移植后各组(C、D、E、F组)CD86表达高于未移植组(A组、B组)(P<0．05)；移植后E组CD86表达高于C组(Po．05)，E组：320±27．39分钟，较C组和D组延长口<0．05)，F组：518±

3、54．95分钟，较E组延长(P

4、：移植；异种；移植物排斥；树突状细胞；核因子-KappaBⅡ研究生：朱幸讽导师：沈振亚教授EffcctsofInhibitingNuclearFactor-KappaBonAcuteVascularRejectionEffectsofInhibitingNuclearFactor-KappaBonAcuteVascularRejectionOBJECTIVES：Toevaluatetheeffectofnuclearfactor-kappaB呷·’国)inhibitorpyrrolidinedithiocarb

5、amate①DTC)onthecell-surfaceexpressionofcostimulatorymolecules(CD80，CD86)ofdendriteiccells①c)andthediscordantcardiacxenograflr叼ectionbythemodelofheterotopiccardiacxenotransplaotationfxomguineapigtoratsusingmodifiedOno’sprocedure，andtoexplorethemechanismsofimm

6、uneosuppressionofxenografLMETHODS：Cardiacxenograflfromguineapigwastl'ansplantodintotheabdomenofSDrat．HyperacuterejectionwasdepletedbyusingChineseCobraVenomFactor(CVF)．TherecipientsWeredividedintosixgroups．GroupA(controlgroup)：withoutpretreatment．GroupB(PDTCg

7、roup)：PDTCwasinjectedintotheabdominalcavitywithadoseof200mg／Kg．GroupC(transplantationgroup)：CardiacxenograftfromguineapigwasWansplantodintotheabdomenofSDrat．GroupD(PDTC+transplantationgroup)：PDTCwasinjectedintotheabdominalcavitywithadoseof200mg／Kgonehourbefo

8、reh-ansplantafion。GroupE(CVF+transplantationgroup)：therecipientsweTe两cotedwithCVF40u／kginabdomenandCVF60u／kgw淝i坷ecteAinveinagainjustbeforetransplantation24hourslater．GroupF(PDTC+CVF+transplantat