欢迎来到天天文库
浏览记录
ID:31991536
大小:2.30 MB
页数:72页
时间:2019-01-30
《蒙药阿给(小白蒿)炮制前后化学成分变化与止血作用机制.研究》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、objectives:AbstractAccordingtothetraditionalethnicmedicinetheoriesandtheclinicalbackgroundofMongoliandrugAgi,tostudytheeffectsofdrug—processingonAgichemicalcompositionsandhemostaticeffects,andtodiscusssomeofthehemostaticmechanismofrawAgiandcharredAgi.Methods:1.Theoptimizedp
2、rocessingprocedurewasscreenedbyorthogonaltestaccordingtocharacters,theclottingtimeandthecontentoftheextraction.2.Thespeciesofflavonoidsinsampleswereidentifiedbycolorreactions,andthecontentsoftotalflavonoidsweremeasuredthroughUVspectroscopyusingrutinascontr01.3.Inorganicelem
3、ents(K,Ca,Mg,Zn,Fe,Mn,Cu,andAI)contentsinrawAgiandcharredAgiweredeterminedbyICP-AES.4.Themousebleedingtimewasmeasuredbytailbreakingtest,andthecloRingtimewasmeasuredbycapillarytest.5.Therabbitbleedingtimewasmeasuredbytraumatichemorrhagetest,andthecloRingtimewasmeasuredbytube
4、test.6.Therabbitprothrombintime(PT),activatedpartialthormboplastia.4.time(APTT),thrombintime(TT),fibrinogen(FIB),plasmarecalcificationtime(PRT),euglobulinlysistime(ELT),maxplateletaggregationrate(MPAR)weremeasuredbysolidificationmethod,turbidimetryandtubetesttoananlyzetheef
5、fectsofrawAgiandcharredAgionrabbitcoagulation-fibrinolysissystemnandplateletfunction.Results:1.Thetemperaturehasthecrucialefflucencesonthedrug’Squality(P<0.05),andtheresultsofanalysisofrangemanifestshowedthatthecharringtimecanalsoaffectthequalityofthedrugincertaindegree.2.T
6、hemaincomponentsoftheflavonoidsinrawAgiareflavoneandflavonol,whilethemaincomponentsofcherredAgiarechalkoneandisoflavone.TheaveragecontentsoftotalflavonoidsinrawandcharredAgiwere4.78%and2.26%respectively.3.ThesequencesofinorganicelementscontainedintherawAgiandcharredAgiareK>
7、Ca>Mg>A1>Fe>Mn>Zn>Cu.Afterdrug—processing,theinorganicelementswereincreasedondifferentdegree,butdissolutionratesweredecreasedapparentlyinwater.4.EffectsofAgionthemouseBTandCT:InthegroupwithmediumdosesandhighdosesofcharredAgi,BTwassignifcantlydeclined(P<0.O1);thehighdosesofr
8、awAgigroup,mediumandhighdosesofcharredAgigroupsmanifestlyshortenedmouseCT(P<0.01).
此文档下载收益归作者所有