卷柏炒炭前后化学成分与其止血作用分析

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1、AbstractStudiesontheChemicalConstituentsandHemostaticactionofSelaginellabeforeandafterbeingcarbonizedWeiShuhui（TraditionalChineseMateriaMedica）DirectedbyLiGenlinAbstractObjective：Toestablishadeterminationmethodandcomparetheeffectofbeingcarbonizedonthecontentsoftotalflavonoidsandament

2、oflavonefromdifferentprocessedproductsSelaginella.TodevelopthestudyonHemostaticActionofdifferentprocessedproductsSelaginella.studyTheEffectofofbeingcarbonizedonitshemostaticeffect.FingerprintspectrumofdifferentprocessedproductsSelaginellawasestablishedinordertoinvestigatethekindsofCh

3、emicalCompositionChangebeforeandafterbeingcarbonized.Investigateontheeffectofbeingcarbonizedprocessingtoprovideevidencefortheclinicalapplication.Methods：Selaginellafriedbeforeandafteritstotalcompositionandcharcoalcomponentcontentbenchmarkchanges:Withethanolconcentration,extractiontem

4、peratureandextractiontimesinordertoinvestigatefactorswithorthogonalmethodisusedtomakethetotalflavonoidsselaginellabestextractiontechnology,anduvspectrophotometry.theselaginellatotalflavonoidscontentindifferentprocessedproductschange;UsingHPLCchromatography,referenceofChinapharmacopoe

5、iacontentdeterminationaboutselaginellarelevantchromatographicconditionswillflowby0.1%ininsteadofphthalicacid-methanol0.1%ofselaginella-methanolofdifferentprocessedproductsofamentoflavoneonthecontentdetermination;Selaginellafriedcarbontostopbleedingaftereffects:Inmicebleedingtimeandbl

6、oodcoagulationtimechangesandratprothrombintime(PT)andactivatepartbloodcoagulationtime(APTT)liveenzymes,clottingfactorsinplasmafibrinogen(FIB)contentchangesforindexexploreselaginellableedingaftertheFriedcarboneffects.DifferentprocessedproductsselaginellaHPLCfingerprintstudy:Methanol-0

7、.1%formicacidasmobilephase,usinggradientelutionanddetected3卷柏炒炭前后化学成分及其止血作用研究-1wavelengthfor330nm,columntemperature30℃,velocity0.8mL•minforselaginella,differentprocessedproducts,usingHPLCanalysisdeterminationCHROMAP1.5fingerprintprocessingsoftware,establishthesimilarityevaluationofdi

8、fferentproce