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1、J圖11山^^因散析2018-03-2712:00:30中国现代医生2018年3期周芳许君贾黎红周杰林张晓晓杨明［摘要］目的探讨川崎病(KD)合并冠状动脉病变的危险因素。方法回顾性分析2014年1月〜2016年12月木院169例KD住院患兒的临床资料；将169例KD分为A、B两组，其屮A组为KD合并冠状动脉病变，B组为KD不伴冠状动脉病变；采用独立样本t检验分析两组年龄、发热天数、白细胞数、超敏C反应蛋0、血沉、血小板数、血清0蛋白、血钠、D二聚体与KD冠状动脉病变的关系；同时采用ROC曲线分析血淸0蛋白、血钠、D二聚体预测冠
2、状动脉病变的效能。结果KD冠状动脉病变发生率为36.69%。A、B组患儿血淸白蛋白、血钠、D二聚体的差异有统计学意义(P<0.05)。ROC曲线分析显示血清白蛋白、血钠、D二聚体曲线下而积分别为0.383、0.353和0.715。血淸白蛋白<35g/L、血钠<135mmol/L、D二聚体>0.92mg/L是KD合并冠状动脉病变的危险因素。结论KD的主耍危害是冠状动脉病变；血清白蛋0<35g/L、血钠<135mmol/L、D二聚体>0.92mg/L足KD合并冠状动脉病变的危险因索。［关键词］川崎病；冠状动脉病变；危险因素；D二聚
3、体［屮图分类号］R725.4［文献标识码］B［义章编号］1673-9了01(2018)03-0056-04AnalysisontheriskfactorsofcoronaryarterydiseaseinchildrenwithKawasakidiseaseZHOUFanglXUJun2JIALihonglZHOUJielin2ZHANGXiaoxiao2YANGMing21.DepartmentofNephrology,HangzhouChildren'sHospital，Hangzhou310014，China；2.Dep
4、artmentofNeurology,HangzhouChildren'sHospital，Hangzhou310014,China［Abstract］ObjectiveToinvestigatetheriskfactorsofKawasakidisease(KD)complicatedwithcoronaryarterydisease.MethodsTheclinicaldataof169childrenwithKDwhowerehospitalizedinourhospitalfromJanuary2014toDecemb
5、er2016wereretrospectivelyanalyzed；the169casesofKDweredividedintotwogroups：groupAandgroupB.GroupAwasKDcomplicatedwithcoronaryarterydisease,andgroupBwasKDwithoutcoronaryarterydisease：therelationshipbetweenage,feverdays,whitebloodcellcount，highsensitivityC-reactiveprot
6、ein，erythrocytesedimentationrate,plateletcount,serumalbumin,serumsodium,DdimerandKDcomplicatedwithcoronaryarterydiseasewereanalyzedbyindependentsamplettest：atthesametime,ROCcurvewasusedtoanalyzetheefficacyofserumalbumin,serumsodiumandDdimerinpredictingcoronaryartery
7、disease.ResultsTheincidencerateofKDcoronaryarterydiseasewas36.69%.Thedifferencesofthelevelsofserumalbumin,serumsodiumandDdimerinchildreningroupAandBwerestatisticallysignificant(P<0.05).ROCcurveanalysisshowedthattheareaunderthecurveofserumalbumin，serumsodiumandDdimer
8、was0.383，0.333and0.715,respectively.Serumalbumin<35g/L,serumsodium<135mmol/L,Ddimer>0.92mg/LweretheriskfactorsofKDcomplicatedwithcoronarya
