化瘀止痛汤联合米非司酮治疗子宫内膜异位症痛经的疗效观察

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1、化瘀止痛汤联合米非司酮治疗子宫内膜异位症痛经的疗效观察［摘要］目的探讨化瘀止痛汤联合小剂量米非司酮治疗子宫内膜异位症(Endometriosis,EM)痛经的临床疗效。方法对92例EM痛经患者随机分为观察组和对照组，对照组于月经第14天开始口服米非司酮片剂6.25mg，每日1次，用药4d。观察组在对照组用药的基础上联合自拟中药化瘀止痛汤，每个月经周期用药4d。两组均3个月经周期用药为1个疗程。结果治疗3个月后观察组痊愈率25.00%，总有效率93.75%。对照组痊愈率9.09%，总有效率70.45%，两组比较差异有显著性(P<0.01)；治疗前后痛经积分疗效比较，观察组治疗前后比较P<0.

2、01，治疗后观察组与对照组比较P<0.01，说明观察组缓解痛经症状较好。结论化瘀止痛汤联合小剂量米非司酮治疗EM痛经疗效明显，具有临床应用价值。［关键词］子宫内膜异位症(EM);痛经；化瘀止痛汤；米非司酮［中图分类号］R711.71［文献标识码］B［文章编号］1673-9701(2011)33-42-02TheEfficacyofHuayuzhitongDecoctionCombinedwithMifepristoneinTreatmentofDysmenorrheaCoursedbyEndometriosisNlXiaojunBAOLanpinDepartmentofGynaceolog

3、yandObstetrics，ZhejiangProvinceLanxiCityTraditionalChineseMedicalHospital，Lanxi321100，China[Abstract]ObjectiveToinvestigatetheclinicaleffectivenessofHuayuzhitongdecoctioncombinedwithmifepristonefordysmenorrheacoursedbyEndometriosis(EM).MethodsAllof92dysmenorrheapatientswithconfirmeddiagnosisofEMwe

4、rerandomlydividedintoobservationgroupandcontrolgroup.Fromthe14thdayinmenstrualcycle,patientsincontrolgroupweregivenmifepristonetablets6.25mgonceperdayfor4days，andpatientsinobservationgroupweregiventhesamedosesofmifepristonecombinedwithself-priscribedChineseherbmedicineHuayuzhitongdecoctionfor4days

5、percycles.Threemenstrualcycleswasacourseoftreatment.ResultsAfter3monthsoftreatmenteffectiveratewas25.00%andtotaleffectiveratewas93.75%intheobservationgroup.Andinthecontrolgrouptheeffectiveratewas9.09%，thetotaleffectiveratewas70.45%.Therewassignificantdifference(P<0.01).Dysmenorrheascoreinobservati

6、ongroupwasdecreaseaftertreatment(P<0.01).Dysmenorrheascoreinobservationgroupwaslowerthancontrolgroup(P<0.01).Itindicatesobservationgroupwasbetterinreliefofdysmenorreha.ConclusionTheclinicaleffectivenessofHuayuzhitongdecoctioncombinedwithmifepristonefordysmenorrheacoursedbyEMisbetterthanmifepriston

7、e,andithasclinicalvalue.[Keywords]Endometriosis(EM)；Dysmenorrhea；Huayuzhitongdecoction；Mifepristone子宫内膜异位症(Endometriosis,EM)是目前妇科领域中的疑难病、多发病，而且呈逐年上升趋势。主要症状表现为痛经、不孕、月经失调及盆腔包块等。其中痛经是最具有特征性的症状，70%〜80%的内异症患者均有不同程度的盆腔