双侧颈动脉重度狭窄分期支架置入术的临床疗效研究

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1、授予单位代码10089学号或申请号20153209中国图书分类号R743.1HebeiMedicalUniversity硕士学位论文专业学位双侧颈动脉重度狭窄分期支架置入术的临床疗效研究研究生：闫建炜导师：郭力教授于江华专业：神经病学二级学院：河北医科大学第二医院2018年3月目录中文摘要······························································································1英文摘要·········································

2、·····················································2英文缩写······························································································4研究论文双侧颈动脉重度狭窄分期支架置入术的临床疗效研究前言······························································································5材料与方法···

3、················································································5结果····························································································14附图····························································································18附表··········

4、··················································································19讨论····························································································31结论····························································································32参考文献·····

5、················································································33综述双侧颈动脉重度狭窄介入治疗的研究进展·································37致谢···································································································60个人简历·········································

6、···················································61中文摘要双侧颈动脉重度狭窄分期支架置入术的临床疗效研究摘要目的：通过回顾性分析23例双侧颈动脉重度狭窄行分期CAS治疗患者的术前、术中及术后随访资料，旨在探求分期支架治疗双侧颈动脉重度狭窄的安全性和临床疗效。方法：收集自2013年3月至2018年1月，河北医科大学第二医院神经介入组收治的症状性双侧颈动脉重度狭窄患者共23例，采取分期支架置入术治疗，分析手术技术成功率、狭窄和临床症状改善程度、术中和围手术期并发症、短期和中期不良临床事件发生率、支架内再狭窄情况及

7、分期手术间隔时间。结果：23例患者的46次手术中，共置入支架47枚，置入成功率100%，46支病变血管的狭窄率由术前86.96±7.49%下降到8.26±5.89%。术前NIHSS、mRS评分分别为1.39±2.08、1.30±0.64，术后90天分别为0.91±1.35、0.52±0.67，有显著改善。围手术期并发症发生率分别为血压心率下降8.7%、高灌注综合征8.7%、缺血发作4.3%。随访时间90天~5年，平均25.43±18.30月，其中随访超过1年的15例，随访90天的2例。短期（90天）不良临床事件发生率4.3%，中期（1年）未有不良临床事件发生及支架

8、内再狭窄，