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1、EGFR及多药耐药相关蛋白在胃食管连接部腺癌中的表达及意义吴金凤1,2秦密密1韩影影1李红1曹璋1【摘要】目的探讨表皮生长因子受体及耐药表型肺耐药相关蛋白在H食管连接部腺癌组织屮的表达及意义。方法采用免疫组化法检测147例胃食管连接部腺癌组织屮EGFR和LRP、GST-π、MDR-1、TopoII的表达情况,分析其与H食管连接部腺癌临床病理参数的关系。结果①H食管连接部腺癌组织屮EGFR、LRP、GST-π、MDR-1和TopoII表达的阳性率分别为39.5%(58/147)、89.1%(131/
2、147)、65.98%(97/147)、56.5%(83/147)和92.5%(136/147);②LRP表达与肿瘤直径和病理分级相关(P<0.05)；GST-π与病理分级和淋巴结转移相关(P<0.05)oTopoII与病理分级相关；EGFR与淋巴结转移相关(P<0.05)；EGFR表达与GST-π、MDR-1表达呈正相关。结论胃食管连接部腺癌组织屮EGFR、LRP、GST-π、MDR-1和TopoII的表达对于判断胃食管连接部腺癌的预后以及有效的个性化治疗具有重要意义。针
3、对EGFR的靶向治疗对化疗耐药、EGFR阳性患者有较好疗效。【关键词】表皮生长因子受体；胃食管连接部腺癌；多药耐药ExpressionofEGFRandMultidrugResistance-associatedProteinsinAdenocarcinomaofEsophagogastricJunctionWuJinfengl,2,QinMimil,HanYingyingl,LiHongl,CaoZhangl.l.DepartmentofPathology,BinzhouMedicalCollege,Bin
4、zhou256603,China；2.DepartmentofGynaecologyandObstetrics,BoxingCountyHospitalofTraditionalChineseMedicine,Boxing256500China【Abstract】ObjectiveToinvestigatetheexpressionsofEGFRandtumorsmultidrugresistancerelatedproteins(LRP,GST-π,MDR-1,TopoII)inadenocarcin
5、omaofesophagogastricjunction(AEJ)toexploretheirfunctionandcorrelationintheoccurrenceanddevelopmentofMDRinAEJ.MethodsWeusedtheimunohistochemistrymethodtodetecttheexpressionsofEGFRandmultidrugresistancerelatedproteins,analyzetheirrelationshipswithclinicaldata
6、in147specmiensofAEJ.ResultsEGFRandmultidrugresistancerelatedproteins(LRP,GST-π'MDR-1,TopoII)expressionwasdetectedin58(39.5%/),131(89.1%),97(65.98%),83(56.5%),136(92.5%)outof147adenocarcinomasofesophagogastricjunction,respectively.Statistically,theexpress
7、ionoftheEGFRproteinwerenotassociatedwithclinicalandpathologicalparameters,includingsex,tumorstage,tumorsizeandtumordifferentiation(P>0.05).TheexpressionoftheEGFRproteinwasassociatedwithlymphnodemetastasis(P<O.O5).Inaddition,asignificantassociationwaso
8、bservedbetweenEGFRandtheexpressionofGST-πandMDR-1inAEJP<0.05)).ConclusionsEGFRandmultidrugresistancerelatedproteinsmayplayanimportantroleincarcinogenesisandprogressionofAEJ,whichmayprovideanewtar
