经肝动脉热化疗栓塞在晚期肝癌治疗中的临床应用

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1、经肝动脉热化疗栓塞在晚期肝癌治疗中的临床应用【摘要】目的：探讨经肝动脉热化疗栓塞在晚期肝癌治疗中的临床应用价值。方法：选取2011年1月-2013年11月本院收治的原发性肝癌晚期患者92例作为研宄对象，依据随机分配原则分为热化疗栓塞组和对照组，每组46例。对照组患者给予常规经肝动脉化疗栓塞治疗，热化疗栓塞组患者给予经肝动脉热化疗栓塞治疗（药物及腆油加热到60°C），检测分析所有患者治疗前后外周血中丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）及总胆红素（TBIL）水平变化；随访24个月，统计分析所有患者有效

2、率和6、12、18、24个月的生存率。结果：热化疗栓塞组有效率为80.43%,明显高于对照组的58.70%,比较差异有统计学意义（P0.05）。结论：经肝动脉热化疗栓塞治疗可有效提高晚期肝癌患者的疗效，有利于延长患者的生存时间，值得临床进一步推【关键词】经肝动脉热化疗栓塞；化疗栓塞；晚期肝癌；生存率ClinicalApplicationofThermochemoembolizationViaHepaticArteryintheTreatmentofAdvancedLiverCancer/CHENGYu,ZHANGSh

3、eng，RAOXiao-hui,etal.//MedicalInnovationofChina，2016,13(22)：051-055【Abstract】Objective:Todiscusstheapplicationvalueofthermochemoembolizationviahepaticarteryinthetreatmentofadvancedlivercancer.Method：FromJanuary2011toNovember2013，92casesofadvancedlivercancerinou

4、rhospitalwereselectedastheresearchobjects，theyweredividedintothethermochemoembolizationgroupandcontrolgroupaccordingtotheprincipleofrandomdistribution,eachgrouphad46cases.Thecontrolgroupreceivedstandardchemoembolizationtherapyviahepaticartery,andthermochemoembo

5、lizationgroupreceivedchemoembolizationwithdrugsheatedto60°Cviahepaticartery.Beforeandafterthetreatment，thelevelsofserumalanineaminotransferase(ALT),aspartateaminotransferase(AST)andtotalbilirubin(TBIL)weredetectedandanalyzed.Allpatientswerefollowedupfor24months

6、,effectiveremissionrateandsurvivalrateof6,12，18，24monthswerestatisticalanalyzed.Result：Thermochemoembolizationgroupeffectiveremissionratewas80.43%,significantlyhigherthan58.70%ofthecontrolgroup，thedifferenceswasstatisticallysignificant(P0.05).Conclusions：Thermo

7、chemoembolizationviahepaticarterycaneffectivelyimprovethecurativeeffectofpatientswithadvancedlivercancer，andisbeneficialtoextendthesurvivaltimeofthesepatients，itisworthoffurtherclinicalpromotion.【Keywords】Thermochemoembolization；Chemoembolization；Advancedliverc

8、ancer；SurvivalrateFirst-author’saddress：CentralPeople'sHospitalofHuizhouCity，Huizhou516001，China2.3两组患者治疗前后外周血中ALT、AST及TBIL水平比较两组患者治疗前外周血中ALT、AST及TBIL水平比较差异均无统计学意义(P>0.05)；治