神经胶质瘤靶向治疗的研究进展

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1、授予单位代码10089学号或申请号20153252中国图书分类号R739.41HebeiMedicalUniversity硕士学位论文专业学位神经胶质瘤靶向治疗的研究进展研究生：韩新旺导师：扈玉华教授专业：外科学二级学院：河北医科大学第二医院2018年3月目录中文摘要············································································································1英文摘要········································

2、····································································2英文缩写············································································································3综述神经胶质瘤靶向治疗的研究进展··························································5致谢····························

3、······················································································28个人简历··········································································································29中文摘要神经胶质瘤靶向治疗的研究进展摘要目的：总结神经胶质瘤靶向治疗的研究进展内容：神经胶质瘤自发现已有百余年，但是恶性神经胶质瘤目前仍不能治愈，且中位无进展生存期(MPFS

4、)及中位总生存期(MOS)都较短。随着科研发展，多条信号通路已被发现，一些新兴靶向抗肿瘤药物应运而生，给神经胶质瘤的医治带来了新希望。本研究通过查阅前人的发现及最新临床试验进展，总结神经胶质瘤的信号通路及相对信号通路的靶向药物，分析神经胶质瘤信号通路之间是否存在相关性，为临床医治胶质瘤提供一定的指导作用。结果：使用万方数据知识服务平台、中国知网、Pubmed等网站查阅近5年国内外期刊、学位论文、著作等，总结分析神经胶质瘤信号通路的新发现、新进展。结论：尽管神经胶质瘤仍然被人们称为是不可治愈的疾病，但是目前的靶向治疗确实使患者的中位无进展生存期及中位总生存期延长了，它也

5、为将成为未来战胜神经胶质瘤的一个强有力武器。关键词：神经胶质瘤,靶向治疗,靶向药物,通路,进展1英文摘要ResearchprogressintargetedtherapyforgliomaABSTRACTObjective:Summarizetheresearchprogressoftargetedtherapyforglioma.Content:Gliomahasbeendiscoveredforover100years,butmalignantgliomacannotbecuredyetatpresent,andthemedianprogressionfreesu

6、rvival(MPFS)andmedianoverallsurvival(MOS)forpatientsareallshort.Withthedevelopmentofscientificresearch,multiplesignalingpathwayshavebeencaughtsightof,atthesametime,someanti-tumordrugshaveemerged,whichbringsnewhopetothetreatmentofglioma.Bylookingupforthepreviousfindingsandthelatestclinic

7、altrials,thestudysummarizesthesignalpathwayaswellastherelativetargetingdrugofglioma,andanalyseswhetherthereisacorrelationbetweengliomasignalingpathwaytoprovidesomeguidanceforclinicaltreatmentofglioma.Results:Bymeansofconsultingtheperiodicals,dissertations,booksandsoonathomeanda