抗生素ppt课件（英文精品）antibiotics cell envelopelecture

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1、1Dr.AlvinFoxAntibiotics:cellenvelope,Lecture282KeyWordsSterilization/disinfection/antisepsisBetalactamAntibioticPenicillinsSelectivetoxicityCephalosporins/cephamycinsBactericidalMonobactamBacteriostaticClavulinicacidMinimalinhibitoryconcentration(MIC)Penicillinase/betalactamaseSuscep

2、tibilitytestingPolymyxinBPenicillinbindingproteinsDaptomycinAutolysinsIsoniazidCycloserineEthioniamideBacitracinEthambutolVancomycinResistance3STERILIZATIONAllkillednon-selective4Sterilizationautoclaving121oC(heat/pressure)HeatresistantmaterialsethyleneoxidenonheatresistantUsuallyequi

3、pmentbeingreplacede.g.H2O2/freeradicalsultra-violetlightsurfaces(e.g.operatingrooms)nottotallyeffectivegammaradiationmainlyfoodindustry5Membranefiltersporesbacteria6DisinfectionLiquidsthatkillbacteriae.g.phenolbasedtootoxicforskinsurfaces7AntisepticsTopical(e.g.skin)e.g.iodineor70%alc

4、ohol“reduce”bacterialload8ANTIBIOTICSSelectivelytoxicforbacteriabactericidal(killing)bacteriostatic(growthinhibition)minimizeharmtopatient9Antibioticsdamagestructurespresentinbacterianotpresentinhost10Antibioticsworktogetherwiththeimmunesystem11Minimalinhibitoryconcentrationlowestleve

5、lstoppinggrowthe.g.zoneofinhibitionaroundadiskimpregnatedwithantibiotic12AntibioticsthatinhibitcellwallbiosynthesisarebactericidalWithoutcellwall,osmoticpressurecausesbacteriatoburst13Cross-linkingofpeptidoglycanOldNew14PeptidoglycansynthesisCytoplasmCellwallundecaprenolsugaraminoacid

6、CellMembrane15CycloserineXCytoplasmsugaraminoacidXXXalanine(ala)analog-inhibitsconversionL-alatoD-ala-inhibitsformationofD-ala-D-ala16BacitracinInhibitsdephosphorylation17TRANSPORTOFPEPTIGOGLYCANSUBUNITACROSSMEMBRANECellmembraneundecaprenolPPCellwall18TRANSPORTOFPEPTIGOGLYCANSUBUNITAC

7、ROSSMEMBRANECellmembraneundecaprenolPPCellwall19TRANSPORTOFPEPTIGOGLYCANSUBUNITACROSSMEMBRANECellmembraneundecaprenolPPCellwall20TRANSPORTOFPEPTIGOGLYCANSUBUNITACROSSMEMBRANECellmembraneundecaprenolPPCellwall21TRANSPORTOFPEPTIGOGLYCANSUBUNITACROSSMEMBRANECellmembraneundecaprenolPPCell

8、wall2