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ID:19698173
大小:8.92 MB
页数:66页
时间:2018-10-05
《embryology of the heart and the great vessels:的心脏和大血管的胚胎学》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、EmbryologyoftheheartandthegreatvesselsDrGerritEngelbrechtDeptofRadiologyUFSESTABLISHMENTOFTHECARDIOGENICFIELDFORMATIONANDPOSITIONOFTHEHEARTTUBEFORMATIONOFTHECARDIACLOOPMOLECULARREGULATIONOFCARDIACDEVELOPMENTDEVELOPMENTOFTHESINUSVENOSUSFORMATIONOFTHECARDIACSEPTAEFORMAT
2、IONOFTHECONDUCTINGSYSTEMOFTHEHEARTVASCULARDEVELOPMENTStepsintheembryologyofthevascularsystemESTABLISHMENTOFTHECARDIOGENICFIELDDorsalviewofalatepresomiteembryo(approximately18days)afterremovaloftheamnion.Prospectivemyoblastsandhemangioblastsresideinthesplanchnicmesoder
3、minfrontoftheneuralplateandoneachsideoftheembryoaftermigratingupfromtheprimitivestreakTransversesectionthroughasimilar-stagedembryotoshowthepositionofthebloodislandsinthesplanchnicmesodermlayer.Withtime,theislandsuniteandformahorseshoe-shapedendothelial-linedtubesurro
4、undedbymyoblasts.ThisregionisknownasthecardiogenicfieldInadditiontothecardiogenicregion,otherbloodislandsappearbilaterally,parallelandclosetothemidlineoftheembryonicshield.Theseislandsformapairoflongitudinalvessels,thedorsalaortae.223Cephalocaudalsectionthroughasimila
5、rstagedembryoshowingthepositionofthepericardialcavityandcardiogenicfield.FORMATIONANDPOSITIONOFTHEHEARTTUBE2processesresponsibleforpositioningoftheheartFoldingoftheembryoinacephalocaudaldirectionSimultanousfoldinglaterallyCephalocaudalfoldingFiguresshowingeffectsofthe
6、rapidgrowthofthebrainonpositioningoftheheart.Initiallythecardiogenicareaandthepericardialcavityareinfrontofthebuccopharyngealmembrane.A.18days.B.20days.C.21days.D.22daysLateralfoldingoftheembryoFormationofthecardiacloopBulbuscordisPrimitiveventricleTheprimitiveatriuma
7、ndsinusvenosusAbnormalitiesofcardiacloopingDextrocardia,inwhichtheheartliesontherightsideofthethoraxinsteadoftheleft,iscausedbecausetheheartloopstotheleftinsteadoftheright.DextrocardiamaycoincidewithsitusinversusMolecularregulationofcardiacdevelopmentDependentontheact
8、ivationoftwotranscriptionfactorsNKX2.5SpecifiescardiogenicfieldSeptationConductionsystemTBX5SeptationDevelopmentofthesinusve
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