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1、通心络胶囊联合阿司匹林预防非瓣膜性心房颤动患者血栓栓塞疗效观察作者：魏峥廖志山孙冠珠张敏【摘要】 目的观察通心络胶囊联合阿司匹林对预防非瓣膜性心房颤动(NVAF)患者血栓栓塞的临床疗效。方法选择符合研究标准的NVAF患者70例,随机分为2组各35例。所有患者均给予基础疾病治疗，治疗组予肠溶阿司匹林150mg，每日1次口服，同时予通心络胶囊，每次3粒，每日3次口服。对照组予肠溶阿司匹林150mg，每日1次口服。观察服药期间症状、体征及凝血酶时间(TT)、活化部分凝血酶时间(APTT)、纤维蛋白原(FIB)、
2、凝血酶原时间(PT)、血栓素B2(TXB2)及左心房血栓形成、栓塞发生情况。以脑中风发病率及凝血指标作为疗效判定依据。结果治疗组无脑栓塞发生；对照组发生左股深、浅静脉内血栓栓塞1例，发生脑栓塞1例。治疗组TXB2、FIB明显降低,PT、TT、APTT均较对照组明显延长，2组比较差异有统计学意义(P<0.05)。结论通心络胶囊联合阿司匹林在预防NVAF患者血栓栓塞方面优于单用阿司匹林，能有效预防血栓栓塞事件发生。【关键词】阿司匹林；心房颤动；脑血管意外；血栓栓塞 Observationonpreven
3、tionofcerebralinfarctionofTongxinluoCapsulecombinedwithAspirinonelderpatientsofthromboembolismwithnonvalvularatrialfibrillation 【Abstract】ObjectiveToobservethepreventionofTongxinluoCapsulecombinedwithAspirinonpatientsofthromboembolismwithnonvalvularatrial
4、fibrillation(NVAF).MethodsSeventypatientswithNVAFwererandomlydividedintotwogroups.Thepatientsincontrolgroup(n=35)wastreatedwithconventionaltreatment,includingtakingAspirin150mgeachday.Thepatientsintreatmentgroup(n=35)wastreatedbycombinationofTongxinluoCaps
5、ule(3tabstid)andAspirin.Weobservedtheclinicalsymptoms,signs,TT,APTT,FIB,PTTXB2,theincreasingoftheleft-atrialpulmonaryembolism.Thehappeningratesofthestrokewasastheclinicaloutcomeparameters.ResultsTherewasnocerebralinfarctionhappenedinthetreatmentgroup.1case
6、incontrolgrouphadpulmonaryembolismsinleft-deepandsuperficialfemoralveinsand1casecerebralinfarctionhappened.TheTXB2andFIBweredecreasedsignificantlyinthetreatmentgroupcomparedtothecontrolgroup(P＜0.05).TT,APTT,PTwereprolongedsignificantlycomparedtothecontrolg
7、roup(P＜0.05).ConclusionTongxinluoCapsuleonpatientswithnonvalvularatrialfibrillationshowsasignificant5effectonimprovingtheindexesofthepre-thromboticStationcomparedwithAspirin,itcanpreventthehappingofthepulmonaryembolism. 【Keywords】TongxinluoCapsule;Aspirin
8、;Pre-thromboticstation 心房颤动（atrialfibrillation,AF）是一种常见的心律失常。AF时由于心房内血流紊乱,流速降低,引起血小板的聚集和频繁的血小板撞击,可导致血小板功能的明显激活［1］，从而发生一系列的变化，引起血小板聚集促使血栓的形成，常常导致脑栓塞的发生。多项大规模临床研究证实抗血栓治疗可以明显降低AF患者脑中风发生率。本研究通过对比通心络胶囊联合阿司匹林与单用阿司
