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1、宫颈鳞状细胞癌局部淋巴管生成与浸润转移及预后的关系作者：林岷,江忠清,连成瑛,郑秀,吴桂珠,曾赛凡【摘要】目的探讨宫颈鳞状细胞癌（SCC）局部淋巴管生成与临床病理特征及预后的关系。方法采用免疫组织化学SP法检测28例正常宫颈上皮(NCE)、36例宫颈上皮内瘤变(CIN)和68例SCC中血管内皮生长因子受体(VEGFR)-3、微淋巴管密度(LMVD)、Ki-67增殖指数(PI)和CD34微血管密度(MVD)。结果LMVD在NCE、CIN及SCC组分别为(2.24±3.82),(6.37±5.69)和(8.29±2.80)。从NCE,CIN到SCC,LMVD显著升高(P<0.01)。SC
2、C组LMVD与盆腔淋巴结转移、间质浸润及预后密切相关(P<0.05),与年龄、FIGO分期、组织学分级、脉管浸润、PI及MVD无显著相关(P>0.05)。SCC有盆腔淋巴结转移及突破深肌层间质浸润者,其LMVD分别显著高于无盆腔淋巴结转移及未突破深肌层间质浸润者(P<0.05)。高LMVD的SCC患者生存率显著低于低LMVD者(P<0.001)。结论SCC局部LMVD升高可能预示肿瘤进展及不良预后。【关键词】宫颈肿瘤,病理学;微淋巴管密度;血管内皮生长因子受体-3;转移;预后;免疫组织化学ABSTRACT:ObjectiveToinvestigatetheassoc
3、iationofregionallymphangiogenesisandclinico-pathologiccharacteristicsandprognosisincervicalsquamouscellcarcinoma.MethodsThelymphaticmicrovesseldensity(LMVD)labeledbyvascularendothelialgrowthfactorreceptor-3（VEGFR-3）,proliferationindex(PI)ofcancercellslabeledbyki-67andmicrovesseldensity(MVD)labeled
4、byCD34in28casesofnormalcervicalepithelium(NCE),36casesofcervicalintraepithelialneoplasm(CIN)and68casesofsquamouscellcarcinomaofcervix(SCC)weredetectedbyimmunohistochemistrySPmethod.ResultsTheLMVDinNCE,CINandSCCgroupwere(2.24±3.82),(6.37±5.69)and(8.29±2.80),respectively.TheLMVDincreasedremarkablyfr
5、omNCEtoCINandSCCaccordingly(P<0.01).InSCC,theLMVDcorrelatedwithpelviclymphnodemetastasis,stromainvolvementandprognosis(P<0.05),butnotcorrelatedwithpatient'sage,FIGOstaging,histologicalgrading,intravascularinfiltration,PIandMVD(P>0.05).Inthecaseswithpelviclymphnodemetastasisanddeeperstroma
6、involvement,theLMVDweresignificantlyhigherthanthatinthosewithouttheconditionsmentionedabove(P<0.05).ThepatientswithhigherLMVDinSCChadsignificantlylowersurvivalratethanthatinthosewiththelowerLMVD(P=0.001).ConclusionThehigherLMVDinSCCmaypredictcancerprogressionandbadprognosis.7KEYWORDS:cervicalne
7、oplasm,pathology;lymphaticmicrovesseldensity;vascularendothelialgrowthfactorreceptor-3;metastasis;prognosis;immunohistochemistry血管内皮生长因子受体-3(vascularendothelialgrowthfactorreceptor-3,VEGFR-3),又称Flt4(fmsliketyrosi
