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1、临床医学论文•宫颈鳞状细胞癌局部淋巴管生成与浸润转移及预后的关系作者：林岷，江忠清，连成瑛，郑秀，吴桂珠，曾赛凡【摘要】H的探讨宫颈鳞状细胞癌(SCC)局部淋巴管生成与临床病理特征及预后的关系。方法采用免疫组织化学SP法检测28例正常宫颈上皮(NCE)、36例宫颈上皮内瘤变(CIN)和68例SCC屮血管内皮生长因子受体(VEGFR)・3、微淋巴管密度(LMVD)、Ki-67增殖指数(PI)和CD34微血管密度(MVD)。结果LMVD在NCE、CIN及SCC组分别为(2.24±3.82),(6.37±5.69)和(8.29土2.80)。从NCE,CIN
2、到SCC,LMVD显着升高(PvO.Ol)。SCC组LMVD与盆腔淋巴结转移、间质浸润及预后密切相关(P<0.05),与年龄、FIGO分期、组织学分级、脉管浸润、PT及MVD无显着相关(P>0,05)oSCC有盆腔淋巴结转移及突破深肌层间质浸润者，其LMVD分别显着高于无盆腔淋巴结转移及未突破深肌层间质浸润者(P<0.05)o高LMVD的SCC患者生存率显着低于低LMVD者(P<0・001)。结论SCC局部LMVD升高可能预示肿瘤进展及不良预后。【关键词】宫颈肿瘤，病理学；微淋巴管密度；血管内皮生长因子受体・3;转移；预后；免疫组织化学ABSTRAC
3、T:ObjectiveToinvestigatetheassociationofregionallymphangiogenesisandclinico・pathologiccharacteristicsandprognosisincervicalsquamouseel1carcinoma・MethodsThelymphaticmicrovcsscldensily(LMVD)labeledbyvascularendolhelialgrowthfactorreceplor-3(VEGFR-3),proliferalionindex(PI)ofcancer
4、cellslabeledbyki-67andmicrovcsscldcnsity(MVD)labeledbyCD34in28easesofnormalcervicalepithelium(NCE),36casesofcervicalintraepithelialneoplasm(CIN)and68casesofsquamouseel1carcinomaofcervix(SCC)weredetectedbyimmunohistochcmistrySPmethod.ResultsTheLMVDinNCE,CINandSCCgroupwere(2.24±3
5、.82),(6.37±5.69)and(8.29±2.80),respectively.TheLMVDincreasedremarkablyfromNCEtoCINandSCCaccordingly(P<0.01)・TnSCC,theLMVDcorrelatedwithpelviclymphnodemetastasis,stromainvolvementandprognosis(P<0.05),butnotcorrelatedwithpatient'sage,FIGOstaging,histologicalgrading,intravasculari
6、nfiltration,PIandMVD(P>0・05)・Inthecaseswithpelviclymphnodemetastasisanddeeperstromainvolvement,theLMVDweresignificantlyhigherthanthatinthosewithouttheconditionsmentionedabove(P<0.05)・ThepatientswithhigherLMVDinSCChadsignificantly1owersurvivalratethanthatinthosewiththe1owerLMVD(
7、P二0.001)・ConclusionThehigherLMVDinSCCmaypredictcancerprogressionandbadprognosis.KEYWORDS:cervicalneoplasm,pathology;lymphaticmicrovesseldensity;vascularendothelialgrowthfactorreceptor・3;metastasis;prognosis;immunohistochemistry血管内皮生长因子受体-3(vascularendothelialgrowthfactortcccpIo
8、t・3,VEGFR・3),又称F114(fmsliketyrosinekinase4),属于血管内皮生长因子
