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1、AdvancedOrganicChemistryMetalsinOrganicSynthesisadvancedorganicchemistryisamasterslevelcoursedesignedtocoverthemanycutting-edgeresearchtopicsandtechniquesofsyntheticorganicchemistrythataresoimportanttothethrivingUKpharmaceuticalandorganicmaterialsindustriessomeaspectsarenotso
2、modern,buttheyareimportantsyntheticmethodologiesthatfindwidespreaduseinresearchandmanufacturingvariousaspectsofsynthesis,retrosynthesis,metalsinorganicsynthesis,heterocyclesthroughdipolarcycloadditions,organicpolymers,andcombinatorialchemistry(alltoincludeaspectsofasymmetrics
3、ynthesis)byRossBoyle,MartinScobie,MikeHird,AndrewBoa,andGeorgMehlthispartofthemoduleconsidersthepreparationandusesofvariouscarbonnegativespeciesintheformoforganometallicsofNa,Li,Mg,Zn,B,Cu,Sn,Si,andhowtheseareessentialinthesynthesisofelaboratecompoundsforpharmaceuticals,natur
4、alproducts,liquidcrystalsetc.someconsiderationwillbegiventoasymmetricsynthesismethodsthatinvolvetheorganometallicsunderdiscussionAdvancedOrganicChemistryisexaminedasmodule06540examwillconsistof(i)MetalsinOrganicSynthesis(2questions),(ii)DipolarCycloadditions(1question),(iii)O
5、rganicPolymers(1question)SynthesisandRetrosynthesisandCombinatorialChemistrywillbothbecontinuouslyassessedmetalsinorganicsynthesisquestionswillbesimilartothosefoundinoldmodules06300/06376and06421recommendedtextsaswithalladvancedcourses,muchoftheworkispartofresearchjournalcont
6、ributions,butthemajorityiscoveredinpartbystandardorganicchemistrytextsandsomeofthemoreadvancedresearchtexts,thefollowingstandardtextsareveryuseful,particularlythelatterOrganicChemistrybySolomonsandFryhle(7thedition)2000OrganicChemistrybyMaitlandJones(2ndEdition)2000OrganicChe
7、mistrybyClayden,Greeves,Warren,Wothers2001IntroductiontoCarbon-minusSpeciescarbonatomsareusuallybondedtoelectronegativeunits,suchasoxygen,nitrogen,fluorine,chlorine,bromine,iodine,sulphur,phosphorusetc.notmanyelementsarelesselectronegativethancarbon,socarbonendsupwithaslightp
8、ositivechargeinthevastmajorityofcompounds-thisisveryrestrictivewheno
