声频共振联合更昔洛韦治疗11[1]

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1、声频共振联合更昔洛韦治疗巨细胞病毒感染患儿听力损伤临床疗效观察何金华张惠佳颜华段华林郭春光湖南省儿童医院康复中心长沙市410007摘要：目的：探讨声频共振耳聋治疗仪治疗联合更昔洛韦巨细胞病毒感染患儿听觉损伤临床疗效。方法：将82例入选患儿随机分为两组，:治疗组(n=41)和对照组(n=41)，治疗组患儿同时予更昔洛韦及声频共振治疗，而对照组只予更昔洛韦治疗，更昔洛韦治疗疗程结束后，两组患儿分别检测CMV-PP65及CMV-DNA检测，比较两组更昔洛韦治疗有效率；声频共振治疗3个疗程后检测纯音听阈

2、，比较两组间疗效的总有效率，比较治疗组不同程度听力损伤有效率。结果：总有效率治疗组为91.2%，对照组为68.9%，两组比较差异有显著性(P<0.05)；声频共振联合更昔洛韦治疗巨细胞病毒感染引起轻度、中度及重度听力损伤疗效有显著差异性。结论　声频共振联合更昔洛韦治疗是巨细胞病毒感染患儿听力损伤有效治疗方法；其治疗轻度及中度听力损伤疗效明显优于重度听力损伤。关键词更昔洛韦；声频共振耳聋治疗仪；巨细胞病毒感染；听力损伤；疗效Clinicaleffectsoftheaudiofrequeneyres

3、onanceandganciclovirtreatmentonthechildrenwithhearingimpairmentduetocytomegalovirusinfection.(HEjinhua，ZHANGhuijia，YANhua，DUANhualin，GUOchunguang.DepartmentofrehabitionHunanChildren’sHospital,Changsha，410007，China)Abstract：objectiveToexploretheclinic

4、curativeeffectsofaudiofrequeneyresonanceandganciclovirthattreatthehearingimpairmentduetocytomegalovirusInfectionininfants.Method82childrenwhowereselectedaccordingwithcriterionweredividedintotwogroups：41casesincontrolgrouptreatedonlywithganciclovirtre

5、atmentand41casesinobservationgrouptreatedadditionallywiththeaudiofrequeneyresonancetreatment.ThelevelsofbloodCMV-pp65andCMV-DNAweredetermined，TheeffectiverateofGanciclovirwerecomparedbeforeandaftertreatmentintwogroups.Pure-toneaudiometryresultsandthe

6、totaleffectiveratebetweentwogroupswerecomparedaftertreatedforthreecourses.Thetotaleffectiveratewerecomparedinobservationgroupwithdifferentdegreeofhearingimpairment.Results　Theeffectiveratewereverysignificantbeforeandaftertreatmentintwogroups(p<0.05).

7、Thetotaleffectiverateoftheobservationgroupwas91.2%,whichwassignificantlyhigherthanthatinthecontrolgroup(68.9%)，(P<0.05).Curativeeffectsoftheaudiofrequeneyresonanceandganciclovirtreatmentonthechildrenwithdeffrentdegreehearingimpairmentduetocytomegalov

8、irusinfectionweresignificantlydefferent（p<0.05）.ConclusionThecombiningtherapyholdsasignificantlysuperiortherapeuticeffectonthechildrenwithhearingimpairmentduetocytomegalovirusinfection…Curativeeffects.oftheslightandmidisthearingimpairmentwereobviousl