分类号 单位代码 10393

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1、福建中医学院2002届儿科学肾脏病专业硕士研究生学位论文THECLINICALRESEARCHONTHERELATIONSHIPBETWEENBLOODTNF-αANDBLOODNOINFREQUENTRELAPSESNEPHROTICSYNDROMEMajor:PediatricmedicineofTCMPostgraduate:DongFeixiaTutor:Prof.ZengZhangchaoABSTRACTObjective:Toinvestigatetherelationshipbetweentumorn

2、ecrosisfactor(TNF-α)andnitricoxide(NO)andFRNS,toevaluatethevalueofTNF-αandNOinpredictingrelapse,toobservethelevelsofplasmaTNFandserumNOeffectedbyQingJieShenKangLingandfurtherexplaintheanti-relapsemechanismofQingJieShenKangLing.Methods:60patientswithFRNSwereran

3、domlydividedintogroupA（QingJieShenKangLing+Westenmedicine）andB（Westenmedicine）,30healthysubjectsservedasgroupC,GroupBseverdasthecontrolgroup.Prednisonewasadoptedinducingremission、transplantingandtaperingmethods;TIIwasadopted24weeksmethods;orCTXwastookorally8we

4、eksorveinpulsion;QingJieShenKangLingwasgivenat15g/time,tidforayear.Veinbloodsamplesofthepatientswerecollectedat8o’clockinthemorningfortestingbeforeandafterthetreatment.TNF-αwastestedbyELISA.NOwastestedbyenzymeassay.SerumCHO,ALB,weretestedbyAutoBiochemistryAnal

5、ysis.Statistical３４福建中医学院2002届儿科学肾脏病专业硕士研究生学位论文analysiswasperformedonSPSS8.0.systemsoftware.Results:ThelevelsofplasmaTNF-αandserumNOofthecaseswithFRNSatrelapseweremarkedlyhigherthanthoseatremissionandgroupC(P<0.01).Aftercompletionoftherapy,therewerenotremarkabl

6、edifferencebetweengroupAandgroupC(p>0.05);thelevelsofplasmaTNF-αwerenotremarkabledifferencebetweengroupBandgroupC(p>0.05);thelevelsofserumNOwereremarkabledifferencebetweengroupBandgroupC(p＜0.01);EffectofgroupAwasbetterthanthatofgroupBaftertreatment(p<0.01).Sid

7、eeffectsingroupAwereobviouslylessthanthoseingroupB.GroupAwasmuchbetterthangroupBincorrectingabnormalityofCHO(p<0.01).studydatashowedthelevelofplasmaTNF-αwaspositivelycorrelatedwiththerelapses（Chi-SquareX2=69.6,TNF-αVariableB=1.2976）,andshowedthesamerelationshi

8、ptoNO.Conclusions:1.PlasmaTNF-αandserumNOmayberegardedasindexofFRNSinactiveperiod.ThelevelofplasmaTNF-αmaypredictthetrendtowardrelapseinchildrenwithFRNS.ThehigherlevelofplasmaTNF-α