肿瘤生物学与转化医学

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1、肿瘤生物学与转化医学Thentheanti-metastasisandrecurrenceeffectofLICARTINwasdeterminedinthepost-orthotopiclivertransplantationOLTHCCpatientsOurinitialresultsshowedthatLICARTINsignificantlydecreasedrecurrencerateandincreasedsurvivalrateofHCCpatientscomparedwithuntreatedcontrolgroupSoLI

2、CARTINisapromisingnewanti-metastasisandrecurrenceagentfortreatingHCCProblemsofCancerBiomarkerNocancerbiomarkerisabsolutelyspecificNocancerbiomarkertestisfreeoffalsenegativesNocancerbiomarkertestisfreeoffalsepositivesNocancerbiomarkerisabsolutelyspecificNocancerbiomarkertes

3、tisfreeoffalsenegativesNocancerbiomarkertestisfreeoffalsepositivesAntibodyBasedCancerBiomarkersCancerMarkerAntibodyCancerCA125OC125ovariancancerCA15-3DF3115D8breastcancerovariancancerCA549BC4E549BC4N154breastcancerovariancancerCA27-29B2729breastcancerMCAb-12breastcancerova

4、riancancerDU-PAN-2Du-PAN-2pancreaticcancerovariancancergastrointestinalcancerslungcancerCA19-919-9pancreaticcancerlivercancergastrointestinalcancersCA19-519-5pancreaticcancerovariancancergastrointestinalcancersCA50C50pancreaticcancerrectalcancergastrointestinalcancersCA72-

5、4B273cc49gastriccarcinomapancreaticcancerovariancancerCA242C242gastrointestinalcancerspancreaticcancerHer-2neuHerceptinbreastcancerHAb18GCD147HAb18hepatocellularcarcinomaectAntibodyBasedCancerBiomarkersHumangenomeis291-billionbasepairsinlength1990Thereareabout25000genesexi

6、stinthehumangenome42haveanunknownfunctionApproximately12000genesthatappeartohavethecapacitytomakesecretedproteinsallthegeneshavebeendeterminedtheentirenucleotidesequences3141geneslocusonthefirstchromosomeAtMay2006thefirstchromosomesequenceswerecompletedatleast1000newgenesw

7、erefoundThisistheendof16yearsHumanGenomicPlanThishasempoweredmoredirectmeansoftargetidentificationegbyexpandingproteindatabasesandenablingthemappingofnovelcancer-associatedgenesVenteretal2001AntibodyBasedCancerBiomarkersCompletegenomesequenceshaveprovidedaplethoraofpotenti

8、aldrugtargetsButthehardtaskoffindingtheirweakspotsisjustbeginningabout5000genescanbeuseda