欢迎来到天天文库
浏览记录
ID:9745170
大小:71.00 KB
页数:12页
时间:2018-05-07
《杀伤细胞免疫球蛋白样受体基因及其配体相合或错配对单倍相合骨髓移植效果的影响》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、杀伤细胞免疫球蛋白样受体基因及其配体相合或错配对单倍相合骨髓移植效果的影响:段连宁韩红星刘静阎洪敏朱玲薛梅丁丽朱培瑜王恒湘纪树荃【摘要】本研究分析杀伤细胞免疫球蛋白样受体(killercellIglikereceptor,KIR)及其配体分子相合与否对单倍体相合骨髓移植效果的影响。分析了74例KIR基因及其配体分子HLACpactofInpatibleKillerCellImmunoglobulinlikeReceptorandItsLigandontheOUteofHaploidenticalpareduchstrongerreactionsbetalignanthematolog
2、icaldiseasebecausetheantileukemiaeffect(GVL)inducedbydonorderivedTcellsostpopularmeasuretopromoteengraftmentandinhibitGVHDisstillbytheblockadeofTcellactivationorbyTcellinhibition/depletioninvivo.ButtheGVLeffectinducedbydonorderivedTcellsisalsoeasures.AnovelresearchabouttheNKimmunologicallikerece
3、ptorfoundthatNKcellscanexertthehomogeneousantileukemiaeffectthroughanoveralldifferentmechanism.DonorderivedhomoreactiveNKcellsplayedakeyroleinimprovingtheeffectofBMT[1].MoreresearchfolloethingtodoinpreventingGVHD,initiatingandpromotingtheengraftmentandinducingtheantileukemiaeffect.TheKIRexpress
4、edonthesurfaceofNKcellsplayedanimportantroleduringtheprocess[2-5].KIRisamemberofimmunologicallikesuperfamilyexpressedonNKcellselyinhibitorygroup(possessingacytoplasmictailbearingimmunoreceptortyrosinebasedinhibitorymotifs,ITIMs)andactivatinggroup(throughadaptorproteintogenerateintracellularsign
5、alsviaimmunoreceptortyrosinebasedactivatingmotifs,ITAMs)munologicaleffect.IftheKIRligandissingbetissingself)theNKcellscoulddisplayheterogeneityevenhomogeneityreactivepotentialtofacilitateGVLanddecreaserelapse,GVHDandtransplantationfailureandprolongoverallsurvival(OS)rate[1,2].Thereforethegenotypi
6、ngofKIRanditsligandhadbeengivenmoreandmoreemphasisrecentlybythescientistsengaginginBMT.UptonoongthemtheinhibitoryKIRgenotypesuchmoreattentionbecauseoftheirrelationsatetheBMTeffectsbyanalyzingthepatibilityofKIRandtheirligands.MostrelatedresearchfocusedontheHLAmatchedBMTtoevaluatetheinpatibilityofKI
7、Rligand,butfepacttoBMTeffectentprocedure.MaterialandMethodsPatientsandDonors74patientsunderber2002toDecember2005,sothatanintactdataaboutKIRgenotypeanditsHLACongthem,32pairsismatchedHLA.GenotypingofHLACinedbyseq
此文档下载收益归作者所有