杀伤细胞免疫球蛋白样受体基因及其配体相合或错配对单倍相合骨髓移植效果的影响论文

《杀伤细胞免疫球蛋白样受体基因及其配体相合或错配对单倍相合骨髓移植效果的影响论文》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、杀伤细胞免疫球蛋白样受体基因及其配体相合或错配对单倍相合骨髓移植效果的影响论文段连宁韩红星刘静阎洪敏朱玲薛梅丁丽朱培瑜王恒湘纪树荃【摘要】本研究分析杀伤细胞免疫球蛋白样受体（killercellIglikereceptor,KIR）及其配体分子相合与否对单倍体相合骨髓移植效果的影响。分析了74例KIR基因及其配体分子HLACpactofInpatibleKillerCellImmunoglobulinlikeReceptorandItsLigandontheOUteofHaploidenticalpareduchstrongerreactionsbetalignanthe

2、matologicaldiseasebecausetheantileukemiaeffect(GVL)inducedbydonorderivedTcellsostpopularmeasuretopromoteengraftmentandinhibitGVHDisstillbytheblockadeofTcellactivationorbyTcellinhibition/depletioninvivo.ButtheGVLeffectinducedbydonorderivedTcellsisalsoeasures.AnovelresearchabouttheNKimmunolog

3、icallikereceptorfoundthatNKcellscanexertthehomogeneousantileukemiaeffectthroughanoveralldifferentmechanism.DonorderivedhomoreactiveNKcellsplayedakeyroleinimprovingtheeffectofBMT［1］.MoreresearchfolloethingtodoinpreventingGVHD,initiatingandpromotingtheengraftmentandinducingtheantileukemiae

4、ffect.TheKIRexpressedonthesurfaceofNKcellsplayedanimportantroleduringtheprocess［2-5］.KIRisamemberofimmunologicallikesuperfamilyexpressedonNKcellselyinhibitorygroup(possessingacytoplasmictailbearingimmunoreceptortyrosinebasedinhibitorymotifs,ITIMs)andactivatinggroup(throughadaptorproteinto

5、generateintracellularsignalsviaimmunoreceptortyrosinebasedactivatingmotifs,ITAMs)munologicaleffect.IftheKIRligandissingbetissingself）theNKcellscoulddisplayheterogeneityevenhomogeneityreactivepotentialtofacilitateGVLanddecreaserelapse,GVHDandtransplantationfailureandprolongoverallsurvival(OS

6、)rate［1，2］.ThereforethegenotypingofKIRanditsligandhadbeengivenmoreandmoreemphasisrecentlybythescientistsengaginginBMT.UptonoongthemtheinhibitoryKIRgenotypesuchmoreattentionbecauseoftheirrelationsatetheBMTeffectsbyanalyzingthepatibilityofKIRandtheirligands.MostrelatedresearchfocusedontheHLAma

7、tchedBMTtoevaluatetheinpatibilityofKIRligand,.freelpacttoBMTeffectentprocedure.MaterialandMethodsPatientsandDonors74patientsunderber2002toDecember2005,sothatanintactdataaboutKIRgenotypeanditsHLACongthem,32pairsismatchedHLA.GenotypingofHLACinedbys