胃内滞留漂浮给药系统中使用草药根除幽门螺旋杆菌的研究进展

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1、胃内滞留漂浮给药系统中使用草药根除幽门螺旋杆菌的研究进展作者：ShreerajH.SHAH,JayvadanK.PATEL,NiravV.PATEL【关键词】幽门螺旋杆菌;胃滞留剂;漂浮剂型;草药;黑柯子;黄连素Helicobacterpyloriareverymonpathogenicbacteriacolonizingabouthalfofallpopulationsandassociatedentofseriousgastroduodenaldiseaseslikegastriclympho

2、ma,pepticulcersandacutechronicgastritis.Currentdrugregimesarenotsrelatedesarelackofpatientpliance,sideeffectsandbacterialresistance.Thus,drugdeliverytothesiteofresidenceinthegastricmucosamayhelpinsolvingtheproblemsassociatedspotentiallyallos,expandableo

3、rssandbioadhesivesystemsarethemajorareasofinteresttoformulategastroretentivedrugdeliverysystemagainstH.pylori.Generally,problemsulationsarelackofspecificityandthedependenceonmucusturnover,sotheyfailtopersistinthestomach.Gastricmucoadhesivesystemsarehail

4、edasapromisingtechnologytoaddressthisissue,peratingthemucuslayerandprolongingactivityatthemucusepithelialinterface.Gastroretentivedeliverystrategies,specificallytotargetHelicobacter,areaveryattractivefieldeinfections.　　H.pyloriisaGramnegative,microaer

5、ophilic,spiralandflagellatedbacterium,otility.Itsspiralshapeandhighmotilityalloucus,resistgastricemptyingandremaininthehostgastrointestinal(GI)tract.Itisnolyestablishedthatinfectionisthecauseofchronicactivegastritis.Itsisolationradicallychangedtheconcep

6、tualisationofseveralchronicgastrointestinalillnessesincludinggastritisandpepticulcers,andeliminationofthecausativeorganismbecamethegoaloftherapies［1］.EstimatesfromtheechanismofH.pyloriinfections　　Infectioninatelyinchildhoodmainlybet,andlastsuntiltheendo

7、flifeilialtransmissionbeingthemajorrouteindevelopedcountries.ThepossibleroutesoftransmissionarefoodandajorfeatureofH.pyloriinfectionisprogressiveinjurytothegastricmucosaanditsfunction［5,6］.Thebacteriumadherestothegastricepithelialcells,producingadirecti

8、njuriouseffectthatisthenamplifiedbyproductionandreleaseofavacuolatingcytotoxin(VacA)［7,8］.H.pyloriproducesavarietyofenzymesandischaracterisedbyahighureaseactivity.Ureaisbrokendomoniathatprotectsthebacteriumintheacidenvironmentoft