胃内滞留漂浮给药系统中使用草药根除幽门螺旋杆菌的研究进展.doc

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1、θÄÚÖÍÁôƯ¸¡¸øҩϵͳÖÐʹÓòÝÒ©¸ù³ýÓÄÃÅÂÝÐý¸Ë¾úµÄÑо¿½øÕ¹×÷ÕߣºShreerajH.SHAH,JayvadanK.PATEL,NiravV.PATEL¡¾¹Ø¼ü´Ê¡¿ÓÄÃÅÂÝÐý¸Ë¾ú;θÖÍÁô¼Á;Ư¸¡¼ÁÐÍ;²ÝÒ©;ºÚ¿Â×Ó;»ÆÁ¬ËØHelicobacterpyloriareverycommonpathoª²genicbacteriacolonizingabouthalfofallpopulationsandassociatedwiththedevelopmentofs

2、eriousgastroduodenaldiseaseslikegastriclymª²phoma,pepticulcersandacutechronicgastritis.Currentdrugregimesarenotwhollyeffective.Otherproblemsrelatedwiththecurrentdrugregimesarelackofpatientcompliance,sideeffectsandbacterialresistance.Thus,drugdeliverytothesiteofresidenceinthegastricmu

3、cosamayhelpinsolvingtheproblemsassociatedwiththecurrentdrugtherapy.Gastricretentivedeliverysystemspotentiallyallowincreasedpenetrationandthusincreaseddrugconcentrationatthesiteofaction.Floatingdrugdeliverysystems,expandableorswellabledrugdeliverysystemsandbioadhesivesystemsarethemajo

4、rareasofinteresttoformulategastroretentivedrugdeliverysystemagainstH.pylori.Generally,problemswiththeseformulationsarelackofspecificityandthedependenceonmucusturnover,sotheyfailtopersistinthestomach.Gastricmucoadhesivesystemsarehailedasapromisingtechnologytoaddressthisissue,penetrati

5、ngthemucuslayerandprolongingactivityatthemucusª²epithelialinterface.Gastroretentivedeliverystrategies,specificallywithregardtotheirapplicationasadeliverysystemtotargetHelicobacter,areaveryattractivefieldwhichcancurethesetroublesomeinfections.¡¡¡¡H.pyloriisaGramª²negative,microaerophi

6、lic,spiralandflagellatedbacterium,withunipolarª²sheathedflagellathatprovidesmotility.Itsspiralshapeandhighmotilityallowsittopenetratemucus,resistgastricemptyingandremaininthehostgastrointestinal(GI)tract.Itisnowfirmlyestablishedthatinfectionwiththisbacteriumisthecauseofchronicactiveg

7、astritis.Itsisolationradicallychangedtheconceptualisationofseveralchronicgastrointestinalillnessesincludinggastritisandpepticulcers,andeliminationofthecausativeorganismbecamethegoaloftherapies£Û1£Ý.EstimatesfromtheWHOin1994claimedthatabouthalfoftheworld¡¯spopulationwasinfectedwithH.p

8、yloriandalth