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1、ElectronicPosters:MolecularCellTrackingIHallBMonday14:00-16:00Computer6714:004166.MonitoringtheUptakeof19FNanoparticlesandinVivoMigrationofDendriticCellsUsingMagneticResonanceHelmarWaiczies1,2,BettinaErdmann3,BerndIttermann1,2,FrankSeifert1,2,ThoralfNiendorf,2,4,SoniaWaicz
2、ies,2,51PhysikalischTechnischeBundesanstalt,10587Berlin,Germany;2BerlinUltrahighFieldFacility,Max-DelbrueckCenterforMolecularMedicine,13125Berlin,Germany;3ElectronMicroscopy,Max-DelbrueckCenterforMolecularMedicine,13125Berlin,Germany;4ExperimentalandClinicalResearchCenter(
3、ECRC),CharitéCampusBuch,Humboldt-University,13125Berlin,Germany;5DepartmentofHematologyandOncology,CharitéCampusBuch,Humboldt-University,13125Berlin,Germany19Fcellularmagneticresonanceimaging(MRI)providessignalselectivityduringcelltrackingandapossibilitytooverlay19F-labele
4、dcellswithanatomic1Hscans.Thisworkinvestigatestheuptakeofnanoparticlescontainingperfluoro-15-crown-5etherindendriticcellsandtheirimpactoncellfunction.19FMRspectroscopyandelectronmicroscopyshowedarapidandefficientuptakeofnanoparticlesbyDC.The19Fsignalintensityinthesecellswa
5、sshowntobedirectlyrelatedto19Fnanoparticlesize.19F/1HMRIshowedthatDCfunctionwasnotdisturbedfollowing19F-labelingasdemonstratedbyanefficientmigrationofthesecellsintodrainingpopliteallymphnodes.14:304167.LongTermEvaluationofthe1.28PpmAfterTransplantationofPurifiedNeuralProge
6、nitorCellsintheBrainChiao-ChiV.Chen1,Kuan-ChiMo1,Ching-YuChuang2,Hung-ChihKuo3,ChenChang11FunctionalandMicro-magneticResonanceImagingCenter,InstituteofBiomedicalSciences,AcademiaSinica,Taipei,Taiwan;2InstituteofBiotechnology,NationalTaiwanUniversity,Taipei,Taiwan;3Institut
7、eofCellularandOrganismicBiology,AcademiaSinica,Taipei,TaiwanThepresentstudyaimedtouseinvivoMRStotrackthelongtermchangesandconsequencesofpurifiedneuralprogenitorcells(NPCs)inthebrain.Followingtransplantation,thereweresignalintensitychangesovertimeatthe1.28ppmalongwiththeNAA
8、signal,whichmayrepresentthevariationsofthefunctionalstatusoftheNPCbiomarker.15:004168.Mol
