阿奇霉素治疗慢性支气管炎合并肺部感染的临床观察

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1、阿奇霉素治疗慢性支气管炎合并肺部感染的临床观叶明霞侯丽萍王保（北京大学深圳医院广东深圳518000）目的探宄阿奇霉素治疗慢性支气管炎合并肺部感染的用药方法和治疗效果。方法回顾分析我院在2011年6月-2012年11月期间收治的66例慢性支气管炎合并肺部感染患者的临床资料，根据患者再治疗期间所采用的用药方法不同，将66例患者随机分为对照组（33例）和观察组各（33例）两组，两组患者均行常规的镇咳、祛痰、平喘和吸氧等常规对症治疗，对照组患者在常规治疗的基础上采用阿莫两林口服治疗，观察组患者在常规治疗的基础上加用阿奇霉素治疗。比较两组患者的治疗有效率和临床并发症情况。结果观察组患者的治疗有效率

2、为96.97%,对照组为81.81%,两组间疗效比较差异明显，具有统计学意义，（PC0.05），且观察组患者的不良反应发生率低于对照组，两组间比较差异明显，只有统计学意义，（P<0.05）。结论阿奇霉素能够有效的抑制慢性支气管炎急性发作，改善患者的肺部感染症状，疗效显著，安全性高，值得临床推广。【关键词】阿奇霉素慢性支气管炎肺部感染阿莫丙林有效率R453A2095-1752（2013）21-0149-02Clinicalobservationofazithromycinintreatmentofchronicbronchitiscomplicatedbypulmonaryinfectio

3、nYeMingxia,HouLiping,WangBao.PekingUniversityShenzhenHospital,Shenzhen,Guangdong518000,China【Abstract】ObjectiveToinvestigatethemedicationsandtreatmenteffectsofazithromycinonchronicbronchitiscomplicatedbypulmonaryinfection.MethodsBetweenJune2011andNovember2012,66patientswithchronicbronchitiscompli

4、catedbypulmonaryinfectionwereadmittedtothehospitalusedinthisstudy.Clinicaldataonthesepatientswereretrospectivelyanalyzed.Accordingtothemedicationsperformedduringtheretreatment,66patientswererandomlydividedintothecontrolgroup(33cases)andtheobservationgroup(33cases).Conventionalsymptomatictreatment

5、ssuchasantitussivetreatment,expectoranttreatment,anti-asthmatictreatment,andoxygenuptakewereperformedforallthepatients.Inadditiontotheconventionaltreatments,oralamoxicillinwasusedforthepatientsinthecontrolgroup,andazithromycinwasusedforthoseintheobservationgroup.Therateofeffectivetreatmentandtheo

6、ccurrenceofclinicalcomplicationswerecomparedforthepatientsinthetwogroups.ResultsTherateofeffectivetreatmentoftheobservationgroupwas96.97%,whilethatofthecontrolgroupwas81.81%.Therewasastatisticallysignificantdifferencebetweenthetwogroups(P<0.05).Also,theincidenceofadversereactionsoftheobservati

7、ongroupwerelowerthanthatofthecontrolgroup,withastatisticallysignificantdifference(P<0.05).ConclusionsAzithromycinmaysuppresstheacuteexacerbationofchronicbronchitiseffectivelyandimprovethepatient’ssymptomsofpul