壳聚糖絮凝沉降法对蒽醌类成分影响的研究

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1、StudyontheeffectofChitosanflocculatingmethodonanthraquinonesSpeciality:PharmacyofTCMAuthor:SunYun-congTutor:LinGui-taoAbstractThisarticleusedthecommonchinesemedicinerhubarbwhichcontainedanthraquinonestoinvestigatetheeffectsofChitosanflocculationonanthraquinones.UsingtheChitosanflocculatingsedimenta

2、tionmethodtorefinethewater-extractedliquidsofsingleherbrhubarbandthecompoundFeedChenHaosoupwhichcontainedrhubarb.Firstly,usingtheL9(34)orthogonaltestmethodtoensurethebestwaterextractiontechnologyofrhubarb.secondly,usingthesamemethodtoselectthebestclarifyprocessofChitosanflocculatingsedimentationme

3、thodtowater-extractedliquidofrhubarb.Selectedthebestclarifyprocess4orthogonaltestmethod.Comparingthecontentofeffectiveingredients,thesizeofotteliaalismoidesrateandthesimilarityoffingerprintafterthenatralclarification.Throughthecompareofthetwoprocesses,wecouldensurethattheclarifiedprocessofChitosanf

4、locculationonwaterextractionliquidoftraditionalChinesemedicinewhichcontainedanthraquinonesbeStabileandfeasible.TheTCMcompoundofvirgatewormwooddecoctioncontainesrhubarb,FeedChenHaoandgardenia.Purifyingthewater-extractedliquidofthiscompoundwithchitosan,sinkingwithalcoholandclarifingnaturallyaccording

5、toexperimentalmedthodofthesingleherbrhubarb,comparingthecontentofeffectiveingredientsofthecompound,thesizeofotteliaalismoidesrateandthesimilarity.Throughthecompare,wecanreachaconclusionthattheclarified4ofAlcoholsinkmethodtowater-extractedliquidofrhubarbwiththeL9(3)processofChitosanflocculationoncom

6、poundmedicinewhichcontainedanthraquinonesalsobeStabileandfeasible.Keywords:rhubarb;virgatewormwooddecoction;anthraquinones;chitosan;alcoholsink;fingerprint5目录引言…………………………………………………………………………………1第一部分研究目的与意义…………………………………………………………..2第二部分药物研究及澄清工艺综述………………………………………………..31壳聚糖澄清工艺研究综述………………………………………………

7、……..32水提醇沉工艺综述……………………………………………………………..43大黄化学成分和药理现代研究……………………………………………………54茵陈蒿汤化学成分和药理现代研究………….………………………………6第三部分壳聚糖絮凝沉降法对蒽醌类成分影响的研究…………..……………..81仪器与材料…………………………………………………………………………82提取工艺的研究……………………………………………