毕业设计（论文）-从d-葡萄糖合成溴-α-d-四乙酰葡萄糖的研究

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1、从D-葡萄糖合成溴-α-D-四乙酰葡萄糖的研究从D-葡萄糖合成溴-α-D-四乙酰葡萄糖的研究摘要：本文介绍了以D葡萄糖、溴等为原料合成糖的溴代衍生物，研究了溴代糖合成反应的条件。以D-葡萄糖为原料，在高氯酸存在下与乙酐反应，将葡萄糖乙酰基化。然后以红磷为催化剂，与液溴反应，将乙酰基化的葡萄糖进行溴化，进而生成所要合成的溴-α-D-四乙酰葡萄糖。结果表明：低温加料，溴代乙酰葡萄糖反应温度控制在30～40℃，并通过熔点测定、HNMR等手段确认了溴-α-D-四乙酰葡萄糖的结构，并鉴定产物纯度较高。经重结晶得到溴-α-D-四乙酰葡萄糖为7.5g。得率为72.

2、8%。关键词：D-葡萄糖、溴、溴-α-D-四乙酰葡萄糖ResearchaboutthesynthesisofTetra-O-acety-α-D-glucopyranosylbromidefromD-glucoseAbstract:thispaperintroducedthesynthesisoftheglucopyranosylbromidefromD-glucoseandbromine,includingtheconditionofthereaction.WiththepresenceofPerchloricAcid,D-glucosereacte

3、dwithaceticanhydridetoproducedacetylatedglycopyranose.Thentheproductreactedwithbromineatthecatalysisofredphosphorusandthefinalproductwasobtained.Theresultsasfollows:it`sbettertomixthestartingmaterialatlowtemperatureandthenraiseditto30-40℃.Thefinalproductwasvalidatedby1H-NMRandm

4、eltingpointevaluatingAnditprovedtobeathighpurity.afterrecrystallization,7.5gTetra-O-acety-α-D-glucopyranosylbromidewasobtainedin72.8%yield.Keywords:D-glucosebromineTetra-O-acety-α-D-glucopyranosylbromide-26-从D-葡萄糖合成溴-α-D-四乙酰葡萄糖的研究目　　　录1前言········································

5、··················································································11.1背景·····················································································································11.2前人合成路线·······························································

6、······································21.2.1半缩醛羟基卤代法·······················································································21.2.2溴代法···········································································································21.2.3酰亚胺盐取代半缩醛羟基法·····

7、··································································41.2.4葡萄糖作糖苷载体法···················································································41.2.5全酯化葡萄糖作糖苷载体法·······································································51.3溴-α-D-四乙酰葡萄糖的合成方法····

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