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ID:5466171
大小:1.59 MB
页数:28页
时间:2017-12-13
《毕业设计(论文)-从d-葡萄糖合成溴-α-d-四乙酰葡萄糖的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、从D-葡萄糖合成溴-α-D-四乙酰葡萄糖的研究从D-葡萄糖合成溴-α-D-四乙酰葡萄糖的研究摘要:本文介绍了以D葡萄糖、溴等为原料合成糖的溴代衍生物,研究了溴代糖合成反应的条件。以D-葡萄糖为原料,在高氯酸存在下与乙酐反应,将葡萄糖乙酰基化。然后以红磷为催化剂,与液溴反应,将乙酰基化的葡萄糖进行溴化,进而生成所要合成的溴-α-D-四乙酰葡萄糖。结果表明:低温加料,溴代乙酰葡萄糖反应温度控制在30~40℃,并通过熔点测定、HNMR等手段确认了溴-α-D-四乙酰葡萄糖的结构,并鉴定产物纯度较高。经重
2、结晶得到溴-α-D-四乙酰葡萄糖为7.5g。得率为72.8%。关键词:D-葡萄糖、溴、溴-α-D-四乙酰葡萄糖ResearchaboutthesynthesisofTetra-O-acety-α-D-glucopyranosylbromidefromD-glucoseAbstract:thispaperintroducedthesynthesisoftheglucopyranosylbromidefromD-glucoseandbromine,includingtheconditionofthe
3、reaction.WiththepresenceofPerchloricAcid,D-glucosereactedwithaceticanhydridetoproducedacetylatedglycopyranose.Thentheproductreactedwithbromineatthecatalysisofredphosphorusandthefinalproductwasobtained.Theresultsasfollows:it`sbettertomixthestartingmat
4、erialatlowtemperatureandthenraiseditto30-40℃.Thefinalproductwasvalidatedby1H-NMRandmeltingpointevaluatingAnditprovedtobeathighpurity.afterrecrystallization,7.5gTetra-O-acety-α-D-glucopyranosylbromidewasobtainedin72.8%yield.Keywords:D-glucosebromineTe
5、tra-O-acety-α-D-glucopyranosylbromide-27-从D-葡萄糖合成溴-α-D-四乙酰葡萄糖的研究目 录1前言··························································································································11.1背景··················································
6、···································································11.2前人合成路线·····································································································21.2.1半缩醛羟基卤代法··························································
7、·····························21.2.2溴代法···········································································································21.2.3酰亚胺盐取代半缩醛羟基法·······································································41.2.4葡萄糖作糖苷载体法·
8、··················································································41.2.5全酯化葡萄糖作糖苷载体法·······································································51.3溴-α-D-四乙酰葡萄糖的合成方法··························································
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