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1、JoséC.PinheiroDouglasM.BatesDepartmentofBiostatisticsDepartmentofStatisticsNovartisPharmaceuticalsUniversityofWisconsinOneHealthPlazaMadison,WI53706-1685EastHanover,NJ07936-1080USAUSAbates@stat.wisc.edujose.pinheiro@pharma.novartis.comSeriesEditors:J.ChambersW.EddyW.HärdleBellLabs,Depar
2、tmentofStatisticsInstitutfürStatistikLucentTechnologiesCarnegieMellonUniversityundÖkonometrie600MountainAve.Pittsburgh,PA15213Humboldt-UniversitätMurrayHill,NJ07974USAzuBerlinUSASpandauerStr.1D-10178BerlinGermanyS.SheatherL.TierneyAustralianGraduateSchoolSchoolofStatisticsofManagementUn
3、iversityofMinnesotaUniversityofNewSouthWalesVincentHallSydneyNSW2052Minneapolis,MN55455AustraliaUSALibraryofCongressCataloging-in-PublicationDataPinheiro,JoséC.Mixed-effectsmodelsinSandS-PLUS/JoséC.Pinheiro,DouglasM.Batesp.cm.—(Statisticsandcomputing)Includesbibliographicalreferencesand
4、index.ISBN978-1-4419-0317-4(softcover)I.Bates,DouglasM.II.Title.III.Series.QA76.73.Sl5P562000005.13′3—dc2199-053566Printedonacid-freepaper.©2000SpringerVerlagNewYork,LLCAllrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewrittenpermissionofthepublisher(Springer-
5、VerlagNewYork,LLC,233SpringStreet,NewYork,NY10013),exceptforbriefexcerptsinconnectionwithreviewsorscholarlyanalysis.Useinconnectionwithanyformofinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisforbidden.
6、Theuseofgeneraldescriptivenames,tradenames,trademarks,etc.,inthispublication,eveniftheformerarenotespeciallyidentified,isnottobetakenasasignthatsuchnames,asunderstoodbytheTradeMarksandMerchandiseMarksAct,mayaccordinglybeusedfreelybyanyone.PrintedintheUnitedStatesofAmerica.SpringerVerlag
7、isapartofSpringerScience+BusinessMediaspringeronline.comPrefaceMixed-effectsmodelsprovideaflexibleandpowerfultoolfortheanalysisofgroupeddata,whichariseinmanyareasasdiverseasagriculture,biology,economics,manufacturing,andgeophysics.Examplesofgroupeddatain-cludelongitudinaldata,rep