二甲双胍影响心脏

《二甲双胍影响心脏》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、CardiovascDrugsTher(2014)28:163–171DOI10.1007/s10557-013-6504-7ORIGINALARTICLEChronicMetforminTreatmentisAssociatedwithReducedMyocardialInfarctSizeinDiabeticPatientswithST-segmentElevationMyocardialInfarctionChrisP.H.Lexis&WouterG.Wieringa&BartHiemstra&VincentM.vanDeursen&Erik

2、Lipsic&PimvanderHarst&DirkJ.vanVeldhuisen&IwanC.C.vanderHorstPublishedonline:1December2013#SpringerScience+BusinessMediaNewYork2013AbstractsmallerMIsize.PatientwithdiabetestreatedwithmetforminPurposeIncreasedmyocardialinfarct(MI)sizeisassociatedhadevensmallerMIsizethanpatients

3、withoutdiabetes.withhigherriskofdevelopingleftventriculardysfunction,ConclusionsChronicmetformintreatmentisassociatedwithheartfailureandmortality.Experimentalstudieshavesug-reducedMIsizecomparedtonon-metforminbasedstrategiesgestedthatmetformintreatmentreducesMIsizeafterinduced

4、indiabeticpatientspresentingwithSTEMI.Metforminmightischaemiabuthumandataislacking.WeaimedtoinvestigatehaveadditionalbeneficialeffectsbeyondglucoseloweringtheeffectofmetforminonMIsizeinpatientspresentingwithefficacy.anacuteMI.MethodsAllconsecutivepatients(n=3,288)presentingtoK

5、eywordsMyocardialinfarction.Metabolism.DiabetesourhospitalwithST-segmentelevationmyocardialinfarctionmellitus.Metformin.Myocardialinfarctsize(STEMI)undergoingprimaryPCIbetweenJanuary2004andDecember2010wereincludedinthisretrospectiveanalysis.Patientswithdiabetesweredividedaccor

6、dingtometforminIntroductionversusnon-metforminbasedpharmacotherapy.MIsizewasestimatedusingpeakvaluesofserumcreatinekinase(CK),Acutemyocardialinfarction(AMI)oftenresultsinmyocardialmyocardialbandofCK(CK-MB),andtroponin-T.damageandimpairedoutcome.DespiteimprovementsinResultsWeid

7、entified677(20.6%)patientswithdiabetes,ofreperfusiontherapyandadditionalpharmacotherapyinthewhom189(27.9%)weretreatedwithmetformin.Chroniclastdecades,mortalityratesremainsubstantialwitha1yearmetformintreatmentwasassociatedwithlowerpeaklevelsofmortalityrateofapproximately10%aso

8、bservedinarecentCK(1,101vs.1,422U/L,P=0.005),CK-MB(152vs.182U