micromonospora an important microbe for biomedicine and potentially

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1、SoilBiology&Biochemistry42(2010)536e542ContentslistsavailableatScienceDirectSoilBiology&Biochemistryjournalhomepage:www.elsevier.com/locate/soilbioReviewMicromonospora:Animportantmicrobeforbiomedicineandpotentiallyforbiocontrolandbiofuelsa,b,*cAnnM.Hirsch,MariaValdésaDepartmentofMolecular,CellandDev

2、elopmentalBiology,UniversityofCalifornia,405HilgardAvenue,LosAngeles,CA90095-1606,USAbMolecularBiologyInstitute,UniversityofCalifornia,405HilgardAvenue,LosAngeles,CA90095-1606,USAcDepartamentodeMicrobiología,EscuelaNacionaldeCienciasBiológicas,I.P.N.,PlandeAyalayCarpio,11340,Mexicoarticleinfoabstrac

3、tArticlehistory:MicromonosporaspecieshavelongbeenrecognizedasimportantsourcesofantibioticsandalsofortheirReceived2September2009unusualspores.However,theirinvolvementinplant-microbeassociationsispoorlyunderstoodalthoughReceivedinrevisedformseveralstudiesdemonstratethatMicromonosporaspeciesfunctioninb

4、iocontrol,plantgrowthpromo-17November2009tion,rootecology,andinthebreakdownofplantcellwallmaterial.OurknowledgeofthisgenerallyAccepted20November2009understudiedgroupofactinomyceteshasbeengreatlyadvancedbytheincreasingnumberofreportsofAvailableonline1December2009theirassociationswithplants,bythedeplo

5、ymentofDNAcloningandmolecularsystematicstechniques,andbytherecentapplicationofwholegenomesequencing.EffortstoannotatethegenomesofseveralKeywords:Micromonosporaspeciesareunderway.ThisinformationwillgreatlyaugmentourknowledgeoftheseActinomycetesBiocontrolversatilemicroorganisms.HydrolyticenzymesÓ2009E

6、lsevierLtd.Allrightsreserved.Secondarymetabolites1.Introductionspeciesalsoproduceanti-tumorantibiotics(lomaiviticinsAandB,tetrocarcinA,LL-E33288complex,etc.)andanthracyclineantibi-AlthoughthegenusMicromonosporahaslongbeenrecognizedotics.Furthermore,theendophyte,Micromonosporalupini,producesasasignifi

7、cantsourceofsecondarymetabolitesforbiomedicinetheanthraquinones,lupinacidinsAandB,whichhaveanti-tumorandsomedatahaveaccruedconcerningtheimportanceoftheseactivity(Igarashietal.,2007).Otherbiologicallya