Outlook：Big data in biomedicine(1)

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1、OUTLOOKBIGDATAINBIOMEDICINE5November2015/Vol527/IssueNo7576tmaynowcostlesstosequencethethreebillionDNAIbasepairsofahumangenomethantodoabrainscan.ButCONTENTShowdoesallthatgenomicdatatranslateintotreatment?LifescientistsarebringingtogetherastonishingvolumesofS2BIGDATAinformationfromgenomicse

2、quencing,labstudiesandpatientThepowerofpetabytesrecords.Andtheresultingeraof‘precisionmedicine’isalreadySearchingformeaninginthedatadeliveringtreatmentstailoredtoindividualneeds.S5Q&AThese‘bigdata’effortsfacehugechallenges,fromcreatingNationalgenomicsanalytictoolsandsolvingscientificpuzzle

3、stoaccessingMarkCaulfielddiscussestheUKCoverart:TatianaPlakhovaapproachtobigdatamillionsofgigabytesofdataandovercomingbarrierstoS6PROTEOMICSEditorialaccessingpatients’healthrecords(seepagesS2andS19).High-proteinresearchHerbBrodyDozensofinternationalprojectsareproducinghugeThechallengeof‘pr

4、acticalgenetics’MichelleGraysonamountsofbiomedicalinformation,notjustonthegenomeEricBenderS8COLLABORATIONSNickHainesbutonmanyother‘-omes’(S8).GiantstridesarebeingmadeMiningthemotherlodesJennyRookeinmappingthehumanproteomeandbuildinga‘partslist’ofInternationalprojectsdigfordataArt&Designthe

5、body(S6).Meanwhile,smartphonesandotherwearableS10CANCERWesleyFernandesdevicesaregeneratingcontinuousflowsofhealthdatafromReshapingthecancerclinicDenisMalletApersonalizedapproachtodiseaselargenumbersofpeople(S12).ThisvastarrayofdatawillallowAnntheaLewisamoredetailedunderstandingofdiseasetra

6、itsinanalysesS12MOBILEDATAProductionMadetomeasureKarlSmartknownasdeepphenotyping(S14).ResearchorganizationsSensingahealthrevolutionIanPopeareassemblingcloud-based‘informationcommons’toS14DEEPPHENOTYPINGMiraLouftistandardize,storeandsharethedata(S16).ThedetailsofdiseaseSponsorshipDrugcompan

7、iesarefacingcomplexchoices(S18).ManyareDeepdataleadstoprecisionmedicineGeorgeSunoptingtotreatcancer,amainthrustinnationalprogrammesS16PERSPECTIVESamanthaMorleysuchastheUK100,000GenomesProject(S5).AndsomeofSustainingthebig-dataecosystemMarketingthesetherapiesar